An efficient approach for identifying important biomarkers for biomedical diagnosis.

Autor: Huang JW; Institute of Statistical Science, Academia Sinica, No. 128, Academia Road, Section 2, Nankang, Taipei, 11529, Taiwan; Institute of Statistics, National Tsing Hua University, Taiwan., Chen YH; Institute of Statistical Science, Academia Sinica, No. 128, Academia Road, Section 2, Nankang, Taipei, 11529, Taiwan., Phoa FKH; Institute of Statistical Science, Academia Sinica, No. 128, Academia Road, Section 2, Nankang, Taipei, 11529, Taiwan. Electronic address: fredphoa@stat.sinica.edu.tw., Lin YH; Institute of Biotechnology, National Taiwan University, Taiwan., Lin SP; Institute of Biotechnology, National Taiwan University, Taiwan; Center for Systems Biology, National Taiwan University, Taiwan; Agricultural Biotechnology Research Center, Academia Sinica, Taiwan. Electronic address: shaupinglin@ntu.edu.tw.
Jazyk: angličtina
Zdroj: Bio Systems [Biosystems] 2024 Mar; Vol. 237, pp. 105163. Date of Electronic Publication: 2024 Feb 22.
DOI: 10.1016/j.biosystems.2024.105163
Abstrakt: In this paper, we explore the challenges associated with biomarker identification for diagnosis purpose in biomedical experiments, and propose a novel approach to handle the above challenging scenario via the generalization of the Dantzig selector. To improve the efficiency of the regularization method, we introduce a transformation from an inherent nonlinear programming due to its nonlinear link function into a linear programming framework under a reasonable assumption on the logistic probability range. We illustrate the use of our method on an experiment with binary response, showing superior performance on biomarker identification studies when compared to their conventional analysis. Our proposed method does not merely serve as a variable/biomarker selection tool, its ranking of variable importance provides valuable reference information for practitioners to reach informed decisions regarding the prioritization of factors for further investigations.
Competing Interests: Declaration of competing interest We declare that this paper has not been previously published in any form, and it is not under consideration nor in press elsewhere. We know of no conflicts of interest associated with this publication, and there has been no significant financial support for this work that could have influenced its outcome.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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