First epileptic seizure and quality of life - A prospective study.

Autor: Linka L; Epilepsy Center Hessen, Philipps-University Marburg, Marburg, Germany. Electronic address: louise.linka@uk-gm.de., Nephuth S; Epilepsy Center Hessen, Philipps-University Marburg, Marburg, Germany., Gorny I; Epilepsy Center Hessen, Philipps-University Marburg, Marburg, Germany., Krause K; Epilepsy Center Hessen, Philipps-University Marburg, Marburg, Germany., Michael Mross P; Epilepsy Center Hessen, Philipps-University Marburg, Marburg, Germany., Tsalouchidou PE; Epilepsy Center Hessen, Philipps-University Marburg, Marburg, Germany., Zahnert F; Epilepsy Center Hessen, Philipps-University Marburg, Marburg, Germany., Fuest S; Epilepsy Center Hessen, Philipps-University Marburg, Marburg, Germany., Menzler K; Epilepsy Center Hessen, Philipps-University Marburg, Marburg, Germany., Knake S; Epilepsy Center Hessen, Philipps-University Marburg, Marburg, Germany; Center for Mind, Brain and Behavior, CMBB, Philipps-University Marburg, Germany., Habermehl L; Epilepsy Center Hessen, Philipps-University Marburg, Marburg, Germany.
Jazyk: angličtina
Zdroj: Epilepsy & behavior : E&B [Epilepsy Behav] 2024 Apr; Vol. 153, pp. 109704. Date of Electronic Publication: 2024 Feb 24.
DOI: 10.1016/j.yebeh.2024.109704
Abstrakt: Objective: Impaired QoL and depression are common in patients with chronic epilepsies; however, data on the impact of a first seizure on QoL are sparse. According to the current ILAE-definition of epilepsy, patients may be diagnosed with epilepsy immediately after the first seizure, if EEG and/or imaging findings are abnormal. Patients with normal findings in imaging and EEG are not diagnosed as having epilepsy. We investigated QoL in patients after a first seizure with and without a consecutive diagnosis of epilepsy to detect differences between groups within the first year after seizure.
Methods: We examined patients (n = 152) after a first epileptic seizure and six and 12 months thereafter using demographic, clinical and QoL-related questionnaire data (Short Form-36 Health Survey (SF-36), Quality of Life in Epilepsy Inventory-31 (QOLIE-31), Beck's depression inventory II (BDI-II)).
Results: Patients diagnosed with epilepsy after the first seizure showed a tendency of reduced mental health-related QoL six (p =.098) and 12 months (p =.092) after the first seizure compared to patients who were not diagnosed with epilepsy, but were diagnosed as having had a single first seizure. There were no significant differences between the two groups in physical health-related QoL. Multiple regression analyses showed that especially depressive symptoms explained 22.0 - 48.7 % of the variance in mental health-related QoL six (p <.001) and 12 months (p <.001) after the first seizure. Physical health-related QoL was especially predicted by age (p <.001), group (p =.002) and recurrent seizures (p = < 0.001). In PWE, there was a statistical trend with improving QOLIE-31 overall scores from six to 12 months (p =.086).
Conclusion: Our results suggest that QoL may be impaired in patients diagnosed with epilepsy early, immediately after the onset of disease. Early follow-up monitoring from the beginning of patient career is important for possible interventions and to improve patients' daily life in the long term.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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