Association between diet quality and ovarian cancer risk and survival.

Autor:	Cao A; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA., Esserman DA; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA., Cartmel B; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.; Yale Cancer Center, New Haven, CT, USA., Irwin ML; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.; Yale Cancer Center, New Haven, CT, USA., Ferrucci LM; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.; Yale Cancer Center, New Haven, CT, USA.
Jazyk:	angličtina
Zdroj:	Journal of the National Cancer Institute [J Natl Cancer Inst] 2024 Jul 01; Vol. 116 (7), pp. 1095-1104.
DOI:	10.1093/jnci/djae040
Abstrakt:	Background: Research on diet quality and ovarian cancer is limited. We examined the association between diet quality and ovarian cancer risk and survival in a large prospective cohort. Methods: We used data from women in the prospective National Institutes of Health-AARP Diet and Health Study enrolled from 1995 to 1996 who were aged 50-71 years at baseline with follow-up through December 31, 2017. Participants completed a 124-item food frequency questionnaire at baseline, and diet quality was assessed via the Healthy Eating Index-2015, the alternate Mediterranean diet score, and the Dietary Approaches to Stop Hypertension score. Primary outcomes were first primary epithelial ovarian cancer diagnosis from cancer registry data and among those diagnosed with ovarian cancer all-cause mortality. We used a semi-Markov multistate model with Cox proportional hazards regression to account for semicompeting events. Results: Among 150 643 participants with a median follow-up time of 20.5 years, 1107 individuals were diagnosed with a first primary epithelial ovarian cancer. There was no evidence of an association between diet quality and ovarian cancer risk. Among those diagnosed with epithelial ovarian cancer, 893 deaths occurred with a median survival of 2.5 years. Better prediagnosis diet quality, according to the Healthy Eating Index-2015 (quintile 5 vs quintile 1: hazard ratio [HR] = 0.75, 95% confidence interval [CI] = 0.60 to 0.93) and alternate Mediterranean diet score (quintile 5 vs quintile 1: HR = 0.68, 95% CI = 0.53 to 0.87), was associated with lower all-cause mortality. There was no evidence of an association between Dietary Approaches to Stop Hypertension score and all-cause mortality. Conclusions: Better prediagnosis diet quality was associated with lower all-cause mortality after ovarian cancer diagnosis but was not associated with ovarian cancer risk. (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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