Persistence of Anti-SE36 Antibodies Induced by the Malaria Vaccine Candidate BK-SE36/CpG in 5-10-Year-Old Burkinabe Children Naturally Exposed to Malaria.

Autor:	Nebie I; Groupe de Recherche Action en Santé (GRAS), Ouagadougou 10248, Burkina Faso., Palacpac NMQ; Department of Malaria Vaccine Development, Research Institute for Microbial Diseases, Osaka University, Suita 565-0871, Osaka, Japan., Bougouma EC; Groupe de Recherche Action en Santé (GRAS), Ouagadougou 10248, Burkina Faso., Diarra A; Groupe de Recherche Action en Santé (GRAS), Ouagadougou 10248, Burkina Faso., Ouédraogo A; Groupe de Recherche Action en Santé (GRAS), Ouagadougou 10248, Burkina Faso., D'Alessio F; European Vaccine Initiative, UniversitätsKlinikum Heidelberg, Voßstraße 2, 69115 Heidelberg, Germany., Houard S; European Vaccine Initiative, UniversitätsKlinikum Heidelberg, Voßstraße 2, 69115 Heidelberg, Germany., Tiono AB; Groupe de Recherche Action en Santé (GRAS), Ouagadougou 10248, Burkina Faso., Cousens S; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK., Horii T; Department of Malaria Vaccine Development, Research Institute for Microbial Diseases, Osaka University, Suita 565-0871, Osaka, Japan., Sirima SB; Groupe de Recherche Action en Santé (GRAS), Ouagadougou 10248, Burkina Faso.
Jazyk:	angličtina
Zdroj:	Vaccines [Vaccines (Basel)] 2024 Feb 06; Vol. 12 (2). Date of Electronic Publication: 2024 Feb 06.
DOI:	10.3390/vaccines12020166
Abstrakt:	Information on the dynamics and decline/persistence of antibody titres is important in vaccine development. A recent vaccine trial in malaria-exposed, healthy African adults and children living in a malaria hyperendemic and seasonal area (Ouagadougou, Burkina Faso) was the first study in which BK-SE36/CpG was administered to different age groups. In 5- to 10-year-old children, the risk of malaria infection was markedly lower in the BK-SE36/CpG arm compared to the control arm. We report here data on antibody titres measured in this age-group after the high malaria transmission season of 2021 (three years after the first vaccine dose was administered). At Year 3, 83% of children had detectable anti-SE36 total IgG antibodies. Geometric mean antibody titres and the proportion of children with detectable anti-SE36 antibodies were markedly higher in the BK-SE36/CpG arm than the control (rabies) arm. The information obtained in this study will guide investigators on future vaccine/booster schedules for this promising blood-stage malaria vaccine candidate.
Databáze:	MEDLINE
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