The Use of Photoactive Polymeric Nanoparticles and Nanofibers to Generate a Photodynamic-Mediated Antimicrobial Effect, with a Special Emphasis on Chronic Wounds.

Autor: Abdel Khalek MA; Institute of Nanoscience and Nanotechnology, Kafrelsheikh University, Kafrelsheikh 33516, Egypt., Abdelhameed AM; Institute of Global Health and Human Ecology, School of Sciences & Engineering, The American University in Cairo, Cairo 11385, Egypt.; Bioscience Research Laboratories Department, MARC for Medical Services and Scientific Research, Giza 11716, Egypt., Abdel Gaber SA; Nanomedicine Department, Institute of Nanoscience and Nanotechnology, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.
Jazyk: angličtina
Zdroj: Pharmaceutics [Pharmaceutics] 2024 Feb 05; Vol. 16 (2). Date of Electronic Publication: 2024 Feb 05.
DOI: 10.3390/pharmaceutics16020229
Abstrakt: This review is concerned with chronic wounds, with an emphasis on biofilm and its complicated management process. The basics of antimicrobial photodynamic therapy (PDT) and its underlying mechanisms for microbial eradication are presented. Intrinsically active nanocarriers (polydopamine NPs, chitosan NPs, and polymeric micelles) that can further potentiate the antimicrobial photodynamic effect are discussed. This review also delves into the role of photoactive electrospun nanofibers, either in their eluting or non-eluting mode of action, in microbial eradication and accelerating the healing of wounds. Synergic strategies to augment the PDT-mediated effect of photoactive nanofibers are reviewed.
Databáze: MEDLINE
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