A Plant-Based Cholesterol-Lowering Diet Score Correlates with Serum LDL-Cholesterol Levels.

Autor:	Polesel J; Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy., Di Maso M; Department of Clinical Sciences and Community Health, Branch of Medical Statistics, Biometry and Epidemiology 'G.A. Maccacaro', Università degli Studi di Milano, 20133 Milan, Italy., Esposito G; Department of Clinical Sciences and Community Health, Branch of Medical Statistics, Biometry and Epidemiology 'G.A. Maccacaro', Università degli Studi di Milano, 20133 Milan, Italy., Vitale S; Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori, IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy., Palumbo E; Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori, IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy., Porciello G; Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori, IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy., Calabrese I; Healthcare Direction, 'A. Cardarelli' Hospital, 80131 Naples, Italy., Minopoli A; Laboratory Medicine Unit, Istituto Nazionale Tumori, IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy., Grilli B; Laboratory Medicine Unit, Istituto Nazionale Tumori, IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy., Cavalcanti E; Laboratory Medicine Unit, Istituto Nazionale Tumori, IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy., Serraino D; Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy., Celentano E; Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori, IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy., Jenkins DJA; Departments of Nutritional Science and Medicine, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON M5C 2T2, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, St. Michael's Hospital, Toronto, ON M5C 2T2, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON M5C 2T2, Canada., Augustin LSA; Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori, IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2024 Feb 08; Vol. 16 (4). Date of Electronic Publication: 2024 Feb 08.
DOI:	10.3390/nu16040495
Abstrakt:	Background: A cholesterol-lowering diet score was previously developed for epidemiological studies; its association with serum lipid profile was not confirmed yet. Methods: The score was developed as an adaptation of the dietary portfolio for cholesterol reduction, assigning one point for adherence to seven dietary indicators and ranging from 0 (null adherence) to 7 (highest adherence). The score was calculated for breast cancer patients enrolled in the DEDiCa study using a 7-day food record; serum lipid profile, including total and low-density lipoprotein cholesterol (LDL-C), was evaluated in serum at baseline. Results: Patients with the highest adherence to the cholesterol-lowering diet (i.e., score ≥ 4) reported lower LDL-C level than women with score 0-1 (median: 107 mg/dL and 122 mg/dL, respectively; p < 0.01). The proportion of women with LDL-C above the recommended limit of 116 mg/dL was 60.0% with score 0-1 and 42.6% with score ≥4. Although the score directly correlates with consumption of foods from vegetal sources, it was mildly associated with the healthful plant-based diet index (r-Spearman = 0.51) and the Mediterranean Diet Adherence Screener (r-Spearman = 0.30) Conclusions: These results provide experimental evidence that the cholesterol-lowering diet score is capable of detecting a specific plant-based dietary pattern that affects circulating cholesterol levels.
Databáze:	MEDLINE
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