The Effect of Rubus idaeus Polyphenols Extract in Induced Endometriosis in Rats.

Autor: Jianu EM; Histology, Department of Morphofunctional Sciences, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Victor Babeș, No 8, 400012 Cluj-Napoca, Romania., Pop RM; Pharmacology, Toxicology and Clinical Pharmacology, Department of Morphofunctional Sciences, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Victor Babeș, No 8, 400012 Cluj-Napoca, Romania., Gherman LM; Experimental Centre, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Louis Pasteur, No 6, 400349 Cluj-Napoca, Romania., Ranga F; Food Science and Technology, Department of Food Science, University of Agricultural Science and Veterinary Medicine, Calea Mănăștur, No 3-5, 400372 Cluj-Napoca, Romania., Levai AM; Obstetrics and Gynecology, Department of Mother and Child, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Victor Babeș, No 8, 400012 Cluj-Napoca, Romania., Rus V; Department of Cell Biology, Histology and Embryology, University of Agricultural Sciences and Veterinary Medicine, Calea Mănăștur, No 3-5, 400372 Cluj-Napoca, Romania., Bolboacă SD; Department of Medical Informatics and Biostatistics, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Louis Pasteur, No 6, 400349 Cluj-Napoca, Romania., Ștefan RA; Histology, Department of Morphofunctional Sciences, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Victor Babeș, No 8, 400012 Cluj-Napoca, Romania., Onofrei MM; Histology, Department of Morphofunctional Sciences, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Victor Babeș, No 8, 400012 Cluj-Napoca, Romania., Nati ID; Obstetrics and Gynecology, Department of Mother and Child, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Victor Babeș, No 8, 400012 Cluj-Napoca, Romania., Stoia IA; Obstetrics and Gynaecology Department County Emergency Hospital, Clinicilor, No 3-5, 400006 Cluj-Napoca, Romania., Ștefan PA; Anatomy and Embryology, Department of Morphological Sciences, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Victor Babeș, No 8, 400012 Cluj-Napoca, Romania., Mihu C; Pharmacology, Toxicology and Clinical Pharmacology, Department of Morphofunctional Sciences, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Victor Babeș, No 8, 400012 Cluj-Napoca, Romania., Mihu CM; Histology, Department of Morphofunctional Sciences, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Victor Babeș, No 8, 400012 Cluj-Napoca, Romania.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2024 Feb 08; Vol. 29 (4). Date of Electronic Publication: 2024 Feb 08.
DOI: 10.3390/molecules29040778
Abstrakt: Endometriosis is a common gynecological condition with a complex physio-pathological background. This study aimed to assess the role of Rubus idaeus leaf extract (RiDE) as a potential therapeutic agent in reducing the size of the endometriotic lesions and modulate the plasma expression of MMP-2, MMP-9, and TGF-β1. The endometriotic lesions were induced in a rat model by the autologous transplant of endometrium. Thirty-six female rats, Wistar breed, with induced endometriosis, were divided into four groups and underwent treatment for 28 days. The CTRL group received 0.5 mL/day of the vehicle; the DG group received 1 mg/kg b.w./day dienogest; the RiDG group received 0.25 mL/kg b.w./day RiDE and the D+RiDG group received 1 mg/kg b.w./day dienogest and 0.25 mL/kg b.w./day RiDE, respectively. Rats' weight, endometriotic lesion diameter and grade, and plasma levels of MMP-2, MMP-9, and TGF-β1 were assessed before and after treatment. The administration of RiDE in association with dienogest vs. dienogest determined a lower weight gain and a reduction in diameter of the endometriotic lesions. RiDE administration restored MMP2 and MMP9 plasma levels to initial conditions. Rubus idaeus extract may help in reducing dienogest-associated weight gain, lower the size of endometriotic lesions, and have anti-inflammatory effects through MMP2 and MMP9 reduction.
Databáze: MEDLINE
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