Hepatoblastoma Relapse-Findings from the German HB99 Trial and the German Liver Tumor Registry.

Autor: Maxwell R; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Lindwurmstraße 4, 80337 Munich, Germany., Häberle B; Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, 80337 Munich, Germany., Kappler R; Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, 80337 Munich, Germany., von Schweinitz D; Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, 80337 Munich, Germany., Rassner M; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Lindwurmstraße 4, 80337 Munich, Germany., von Frowein J; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Lindwurmstraße 4, 80337 Munich, Germany., Schmid I; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Lindwurmstraße 4, 80337 Munich, Germany.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2024 Feb 06; Vol. 16 (4). Date of Electronic Publication: 2024 Feb 06.
DOI: 10.3390/cancers16040696
Abstrakt: Survival rates for HB patients have improved; however, outcomes for patients who relapse remain poor. A retrospective review of information gathered for the HB99 study and the German Liver Tumor Registry identified 25 relapse patients (6.9%, 25/362). The median time from initial diagnosis to first relapse was 13 months (range: 5-66 months). Two patients relapsed >36 months after initial diagnosis. A total of 68% (17/25) of relapses were metastatic, 24% local, and 8% combined. 67% of local relapses were alive at the last follow-up, in contrast to 53% of metastatic and 0% of combined relapses. At the last follow-up, 73% (8/11) of patients with lung relapses were still alive (0/4 with peritoneal, 1/2 with CNS involvement). A total of 20% of the patients had AFP-negative relapses, 64% of the relapse patients achieved a second complete remission, 69% were still in complete second remission at the last follow-up (median FU of 66 months), and 83% (5/6) of irinotecan-naïve patients who received relapse treatment including irinotecan were in second complete remission at the last follow-up. The 3-year overall survival/event-free survival from relapse was 63%/48% respectively. There is a good chance that HB patients will achieve a second remission despite a first relapse. However, patients who suffer further relapses tend to have a poorer prognosis.
Competing Interests: The authors declare no conflicts of interest.
Databáze: MEDLINE
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