Pathophysiology, Histopathology, and Differential Diagnostics of Basal Cell Carcinoma and Cutaneous Squamous Cell Carcinoma-An Update from the Pathologist's Point of View.

Autor: Cocuz IG; Pathophysiology Department, 'George Emil Palade' University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania.; Pathology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania., Popelea MC; Pathology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania., Niculescu R; Pathophysiology Department, 'George Emil Palade' University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania.; Pathology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania., Manea A; Faculty of Medicine, 'George Emil Palade' University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania., Sabău AH; Pathophysiology Department, 'George Emil Palade' University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania.; Pathology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania., Tinca AC; Pathophysiology Department, 'George Emil Palade' University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania.; Pathology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania., Szoke AR; Pathophysiology Department, 'George Emil Palade' University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania.; Pathology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania., Budin CE; Pathophysiology Department, 'George Emil Palade' University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania.; Pneumology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania., Stoian A; Pathophysiology Department, 'George Emil Palade' University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania.; Neurology I Clinic, Targu Mures Emergency County Hospital, 540136 Targu Mures, Romania., Morariu SH; Dermatology Department, 'George Emil Palade' University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania.; Dermatology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania., Cotoi TC; Pharmaceutical Technique Department, 'George Emil Palade' University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania.; Pharmacy No. 2, Mures Clinical County Hospital, 540011 Targu Mures, Romania., Cocuz ME; Fundamental Prophylactic and Clinical Disciplines Department, Faculty of Medicine, Transilvania University of Brasov, 500003 Brașov, Romania.; Clinical Pneumology and Infectious Diseases Hospital of Brasov, 500174 Brasov, Romania., Cotoi OS; Pathophysiology Department, 'George Emil Palade' University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania.; Pathology Department, Mures Clinical County Hospital, 540011 Targu Mures, Romania.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 13; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 13.
DOI: 10.3390/ijms25042220
Abstrakt: Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are the most frequently occurring non-melanocytic skin cancers. The objective of our study is to present the pathophysiology of BCC and cSCC and its direct relationship with the histopathological diagnostics and the differential diagnostics of these types of cancer, based on the morphological characteristics, immunohistochemical profile, and genetic alterations. The qualitative study was based on emphasizing the morphological characteristics and immunohistochemistry profiles of BCC and cSCC and the differential diagnostics based on the tissue samples from the Clinical Pathology Department of Mures Clinical County Hospital between 2020 and 2022. We analyzed the histopathological appearances and immunohistochemical profiles of BCC and cSCC in comparison with those of Bowen disease, keratoacanthoma, hyperkeratotic squamous papilloma, metatypical carcinoma, pilomatricoma, trichoblastoma, Merkel cell carcinoma, pleomorphic dermal sarcoma (PDS), and melanoma. Our study showed the importance of the correct histopathological diagnosis, which has a direct impact on the appropriate treatment and outcome for each patient. The study highlighted the histopathological and morphological characteristics of NMSCs and the precursor lesions in HE and the immunohistochemical profile for lesions that may make the differential diagnosis difficult to establish.
Databáze: MEDLINE
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