Correlation between Histopathological Prognostic Tumor Characteristics and [ 18 F]FDG Uptake in Corresponding Metastases in Newly Diagnosed Metastatic Breast Cancer.

Autor: Boers J; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands., Eisses B; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands., Zwager MC; Department of Pathology, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands., van Geel JJL; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands., Bensch F; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands., de Vries EFJ; Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands., Hospers GAP; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands., Glaudemans AWJM; Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands., Brouwers AH; Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands., den Dekker MAM; Department of Radiology, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands., Elias SG; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, 3584 Utrecht, The Netherlands., Kuip EJM; Department of Medical Oncology, Radboud Medical Center, 6500 Nijmegen, The Netherlands., van Herpen CML; Department of Medical Oncology, Radboud Medical Center, 6500 Nijmegen, The Netherlands., Jager A; Department of Medical Oncology, Erasmus MC Cancer Institute, 3015 Rotterdam, The Netherlands., van der Veldt AAM; Department of Medical Oncology, Erasmus MC Cancer Institute, 3015 Rotterdam, The Netherlands., Oprea-Lager DE; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Location VU University Medical Center, 1081 Amsterdam, The Netherlands., de Vries EGE; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands., van der Vegt B; Department of Pathology, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands., Menke-van der Houven van Oordt WC; Department of Medical Oncology, Amsterdam University Medical Center, Location VU University Medical Center, 1081 Amsterdam, The Netherlands., Schröder CP; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, 9713 Groningen, The Netherlands.; Department of Medical Oncology, Dutch Cancer Institute, 1066 Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2024 Feb 14; Vol. 14 (4). Date of Electronic Publication: 2024 Feb 14.
DOI: 10.3390/diagnostics14040416
Abstrakt: Background: In metastatic breast cancer (MBC), [ 18 F]fluorodeoxyglucose positron emission tomography/computed tomography ([ 18 F]FDG-PET/CT) can be used for staging. We evaluated the correlation between BC histopathological characteristics and [ 18 F]FDG uptake in corresponding metastases.
Patients and Methods: Patients with non-rapidly progressive MBC of all subtypes prospectively underwent a baseline histological metastasis biopsy and [ 18 F]FDG-PET. Biopsies were assessed for estrogen, progesterone, and human epidermal growth factor receptor 2 (ER, PR, HER2); Ki-67; and histological subtype. [ 18 F]FDG uptake was expressed as maximum standardized uptake value (SUV max ) and results were expressed as geometric means.
Results: Of 200 patients, 188 had evaluable metastasis biopsies, and 182 of these contained tumor. HER2 positivity and Ki-67 ≥ 20% were correlated with higher [ 18 F]FDG uptake (estimated geometric mean SUV max 10.0 and 8.8, respectively; p = 0.0064 and p = 0.014). [ 18 F]FDG uptake was lowest in ER-positive/HER2-negative BC and highest in HER2-positive BC (geometric mean SUV max 6.8 and 10.0, respectively; p = 0.0058). Although [ 18 F]FDG uptake was lower in invasive lobular carcinoma ( n = 31) than invasive carcinoma NST ( n = 146) (estimated geometric mean SUV max 5.8 versus 7.8; p = 0.014), the metastasis detection rate was similar.
Conclusions: [ 18 F]FDG-PET is a powerful tool to detect metastases, including invasive lobular carcinoma. Although BC histopathological characteristics are related to [ 18 F]FDG uptake, [ 18 F]FDG-PET and biopsy remain complementary in MBC staging (NCT01957332).
Databáze: MEDLINE
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