Supplementation with antioxidant micronutrients in pregnant women with obesity: a randomized controlled trial.

Autor: Sen S; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA. Ssen2@bwh.harvard.edu.; JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA. Ssen2@bwh.harvard.edu.; Harvard Medical School, Boston, MA, USA. Ssen2@bwh.harvard.edu., Cherkerzian S; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Herlihy M; Harvard Medical School, Boston, MA, USA.; Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA., Hacker MR; Harvard Medical School, Boston, MA, USA.; Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA., McElrath TF; Harvard Medical School, Boston, MA, USA.; Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA., Cantonwine DE; Harvard Medical School, Boston, MA, USA.; Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA., Fichorova R; Harvard Medical School, Boston, MA, USA.; Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA., Oken E; Harvard Medical School, Boston, MA, USA.; Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA., Meydani SN; JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
Jazyk: angličtina
Zdroj: International journal of obesity (2005) [Int J Obes (Lond)] 2024 Jun; Vol. 48 (6), pp. 796-807. Date of Electronic Publication: 2024 Feb 23.
DOI: 10.1038/s41366-024-01472-z
Abstrakt: Background/objective: Obesity increases maternal morbidity and adversely affects child health. Maternal inflammation may play a role in adverse outcomes. The objective of this study was to determine whether providing a higher dose of antioxidant micronutrients to pregnant women with obesity would raise concentrations of key antioxidant vitamins and impact inflammation and oxidative stress during pregnancy.
Subjects/methods: This was a double-blind, randomized controlled trial. We recruited pregnant women with a body mass index (BMI) ≥ 30 kg/m 2 at their initial prenatal visit ( < 13 weeks gestation) and collected blood and urine samples at baseline, 24-28 weeks, and 32-36 weeks to measure micronutrient concentrations (vitamin C, E, B 6 and folate), markers of inflammation (C-reactive protein, interleukin-6, 8, and 1β) and oxidative stress (8-epi-PGF2α and malondialdehyde). We collected maternal and infant health data from enrollment to delivery as secondary outcomes. We enrolled 128 participants (64 in each arm), and 98 (49 in each arm) completed follow-up through delivery.
Intervention: Both groups received a standard prenatal vitamin containing the recommended daily allowance of micronutrients in pregnancy. In addition, the intervention group received a supplement with 90 mg vitamin C, 30 αTU vitamin E, 18 mg vitamin B 6 , and 800 μg folic acid, and the control group received a placebo.
Results: The intervention group had higher vit B 6 (log transformed (ln), β 24-28 weeks: 0.76 nmol/L (95% CI: 0.40, 1.12); β 32-36 weeks: 0.52 nmol/L (95% CI: 0.17, 0.88)) than the control group. Vitamins C, E, erythrocyte RBC folate concentrations did not differ by randomization group. The intervention did not impact biomarkers of inflammation or oxidative stress. There were no differences in maternal or neonatal clinical outcomes by randomization group.
Conclusions: Higher concentrations of antioxidant vitamins during pregnancy increased specific micronutrients and did not impact maternal inflammation and oxidative stress, which may be related to dosing or type of supplementation provided.
Clinical Trial Registration: Clinical Trial Identification Number: NCT02802566; URL of the Registration Site: www.
Clinicaltrials: gov .
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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