Antioxidant, antimicrobial and healing properties of an extract from coffee pulp for the development of a phytocosmetic.

Autor: Dos Santos ÉM; Faculdade de Ciências Farmacêuticas, Universidade de Campinas (UNICAMP), Rua Cândido Portinari, 200, Campinas, São Paulo, 13083-871, Brazil., de Macedo LM; Faculdade de Ciências Médicas, Universidade de Campinas (UNICAMP), Rua Tessália Vieira de Camargo, 126, Campinas, São Paulo, 13083-887, Brazil., Ataide JA; Faculdade de Ciências Farmacêuticas, Universidade de Campinas (UNICAMP), Rua Cândido Portinari, 200, Campinas, São Paulo, 13083-871, Brazil. janaina.a.ataide@gmail.com., Delafiori J; Faculdade de Ciências Farmacêuticas, Universidade de Campinas (UNICAMP), Rua Cândido Portinari, 200, Campinas, São Paulo, 13083-871, Brazil., de Oliveira Guarnieri JP; Faculdade de Ciências Farmacêuticas, Universidade de Campinas (UNICAMP), Rua Cândido Portinari, 200, Campinas, São Paulo, 13083-871, Brazil., Rosa PCP; Faculdade de Ciências Farmacêuticas, Universidade de Campinas (UNICAMP), Rua Cândido Portinari, 200, Campinas, São Paulo, 13083-871, Brazil., Ruiz ALTG; Faculdade de Ciências Farmacêuticas, Universidade de Campinas (UNICAMP), Rua Cândido Portinari, 200, Campinas, São Paulo, 13083-871, Brazil., Lancellotti M; Faculdade de Ciências Farmacêuticas, Universidade de Campinas (UNICAMP), Rua Cândido Portinari, 200, Campinas, São Paulo, 13083-871, Brazil., Jozala AF; Laboratory of Industrial Microbiology and Fermentation Process (LAMINFE), University of Sorocaba, Sorocaba, São Paulo, 18023-000, Brazil., Catharino RR; Faculdade de Ciências Farmacêuticas, Universidade de Campinas (UNICAMP), Rua Cândido Portinari, 200, Campinas, São Paulo, 13083-871, Brazil., Camargo GA; Institute of Food Technology, ITAL, Av. Brasil, 2880, Campinas, São Paulo, 13070-178, Brazil., Paiva-Santos AC; Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal.; REQUIMTE/LAQV, Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal., Mazzola PG; Faculdade de Ciências Farmacêuticas, Universidade de Campinas (UNICAMP), Rua Cândido Portinari, 200, Campinas, São Paulo, 13083-871, Brazil.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Feb 23; Vol. 14 (1), pp. 4453. Date of Electronic Publication: 2024 Feb 23.
DOI: 10.1038/s41598-024-54797-0
Abstrakt: Consumer demand for natural, chemical-free products has grown. Food industry residues, like coffee pulp, rich in caffeine, chlorogenic acid and phenolic compounds, offer potential for pharmaceutical and cosmetic applications due to their antioxidant, anti-inflammatory, and antibacterial properties. Therefore, the objective of this work was to develop a phytocosmetic only with natural products containing coffee pulp extract as active pharmaceutical ingredient with antioxidant, antimicrobial and healing activity. Eight samples from Coffea arabica and Coffea canephora Pierre were analyzed for caffeine, chlorogenic acid, phenolic compounds, tannins, flavonoids, cytotoxicity, antibacterial activity, and healing potential. The Robusta IAC-extract had the greatest prominence with 192.92 μg/mL of chlorogenic acid, 58.98 ± 2.88 mg GAE/g sample in the FRAP test, 79.53 ± 5.61 mg GAE/g sample in the test of total phenolics, was not cytotoxic, and MIC 3 mg/mL against Staphylococcus aureus. This extract was incorporated into a stable formulation and preferred by 88% of volunteers. At last, a scratch assay exhibited the formulation promoted cell migration after 24 h, therefore, increased scratch retraction. In this way, it was possible to develop a phytocosmetic with the coffee pulp that showed desirable antioxidant, antimicrobial and healing properties.
(© 2024. The Author(s).)
Databáze: MEDLINE
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