Deficiency of nucleosome-destabilizing factor GLYR1 dampens spermatogenesis in mice.

Autor: Cheng GP; Department of Women Health Care, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Wang YF; Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Li YY; Department of Gynecology and Obstetrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Guo SM; Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Li HG; Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Ji DM; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Anhui, China. Electronic address: jidongmei@ahmu.edu.cn., Yi NH; Department of Women Health Care, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: ynh1996@163.com., Zhou LQ; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Anhui, China. Electronic address: zhouliquan@hust.edu.cn.
Jazyk: angličtina
Zdroj: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2024 May 15; Vol. 586, pp. 112194. Date of Electronic Publication: 2024 Feb 21.
DOI: 10.1016/j.mce.2024.112194
Abstrakt: Aberrant sperm morphology hinders sperm motility and causes male subfertility. Spermatogenesis, a complex process in male germ cell development, necessitates precise regulation of numerous developmental genes. However, the regulatory pathways involved in this process remain partially understood. We have observed the widespread expression of Glyr1, the gene encoding a nucleosome-destabilizing factor, in mouse testicular cells. Our study demonstrates that mice experiencing Glyr1 depletion in spermatogenic cells exhibit subfertility characterized by a diminished count and motility of spermatozoa. Furthermore, the rate of sperm malformation significantly increases in the absence of Glyr1, with a predominant occurrence of head and neck malformation in spermatozoa within the cauda epididymis. Additionally, a reduction in spermatocyte numbers across different meiotic stages is observed, accompanied by diminished histone acetylation in spermatogenic cells upon Glyr1 depletion. Our findings underscore the crucial roles of Glyr1 in mouse spermiogenesis and unveil novel insights into the etiology of male reproductive diseases.
Competing Interests: Declaration of competing interest The authors declare no competing interests.
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Databáze: MEDLINE
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