Review of multiple sclerosis: Epidemiology, etiology, pathophysiology, and treatment.

Autor:	Haki M; Department of Pharmacy, Bilad Alrafidain University College, Diyala, Iraq., Al-Biati HA; Department of Pharmacy, Bilad Alrafidain University College, Diyala, Iraq., Al-Tameemi ZS; Department of Pharmacy, Bilad Alrafidain University College, Diyala, Iraq.; Dr. Hany Akeel Institute, Iraqi Medical Research Center, Baghdad, Iraq., Ali IS; Department of Pharmacy, Bilad Alrafidain University College, Diyala, Iraq., Al-Hussaniy HA; Department of Pharmacy, Bilad Alrafidain University College, Diyala, Iraq.; Dr. Hany Akeel Institute, Iraqi Medical Research Center, Baghdad, Iraq.; Department of Pharmacology, College of Medicine, University of Baghdad, Baghdad, Iraq.
Jazyk:	angličtina
Zdroj:	Medicine [Medicine (Baltimore)] 2024 Feb 23; Vol. 103 (8), pp. e37297.
DOI:	10.1097/MD.0000000000037297
Abstrakt:	Multiple sclerosis (MS) is a chronic autoimmune disease with demyelination, inflammation, neuronal loss, and gliosis (scarring). Our object to review MS pathophysiology causes and treatment. A Narrative Review article was conducted by searching on Google scholar, PubMed, Research Gate about relevant keywords we exclude any unique cases and case reports. The destruction of myelinated axons in the central nervous system reserves this brunt. This destruction is generated by immunogenic T cells that produce cytokines, copying a proinflammatory T helper cells1-mediated response. Autoreactive cluster of differentiation 4 + cells, particularly the T helper cells1 subtype, are activated outside the system after viral infections. T-helper cells (cluster of differentiation 4+) are the leading initiators of MS myelin destruction. The treatment plan for individuals with MS includes managing acute episodes, using disease-modifying agents to decrease MS biological function of MS, and providing symptom relief. Management of spasticity requires physiotherapy, prescription of initial drugs such as baclofen or gabapentin, secondary drug options such as tizanidine or dantrolene, and third-line treatment such as benzodiazepines. To treat urinary incontinence some options include anticholinergic medications such as oxybutynin hydrochloride, tricyclic antidepressants (such as amitriptyline), and intermittent self-catheterization. When it comes to bowel problems, one can try to implement stool softeners and consume a high roughage diet. The review takes about MS causes Pathophysiology and examines current treatment strategies, emphasizing the advancements in disease-modifying therapies and symptomatic treatments. This comprehensive analysis enhances the understanding of MS and underscores the ongoing need for research to develop more effective treatments. Competing Interests: The authors have no funding and conflicts of interest to disclose. (Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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