Enhancing the safety of CAR-T cell therapy: Synthetic genetic switch for spatiotemporal control.

Autor:	Lu L; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, China., Xie M; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.; Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, Hangzhou, Zhejiang 310024, China.; School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310024, China.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang 310024, China., Yang B; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, China.; School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China.; Engineering Research Center of Innovative Anticancer Drugs, Ministry of Education, Hangzhou, China., Zhao WB; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, China., Cao J; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.; Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, China.; Engineering Research Center of Innovative Anticancer Drugs, Ministry of Education, Hangzhou, China.; Cancer Center, Zhejiang University, Hangzhou, China.
Jazyk:	angličtina
Zdroj:	Science advances [Sci Adv] 2024 Feb 23; Vol. 10 (8), pp. eadj6251. Date of Electronic Publication: 2024 Feb 23.
DOI:	10.1126/sciadv.adj6251
Abstrakt:	Chimeric antigen receptor T (CAR-T) cell therapy is a promising and precise targeted therapy for cancer that has demonstrated notable potential in clinical applications. However, severe adverse effects limit the clinical application of this therapy and are mainly caused by uncontrollable activation of CAR-T cells, including excessive immune response activation due to unregulated CAR-T cell action time, as well as toxicity resulting from improper spatial localization. Therefore, to enhance controllability and safety, a control module for CAR-T cells is proposed. Synthetic biology based on genetic engineering techniques is being used to construct artificial cells or organisms for specific purposes. This approach has been explored in recent years as a means of achieving controllability in CAR-T cell therapy. In this review, we summarize the recent advances in synthetic biology methods used to address the major adverse effects of CAR-T cell therapy in both the temporal and spatial dimensions.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu