Prominent genetic variants and epigenetic changes in post-traumatic stress disorder among combat veterans.

Autor: Baghaei A; Trauma Research center, AJA university of Medical sciences, Tehran, Iran., Zoshk MY; Trauma Research center, AJA university of Medical sciences, Tehran, Iran., Hosseini M; The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran., Fasihi H; Biomaterial and Medicinal Chemistry Research Center, AJA University of Medical Science, Tehran, Iran., Nassireslami E; Toxicology Research Center, AJA University of Medical Sciences, Tehran, Iran.; Department of Pharmacology and Toxicology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran., Shayesteh S; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran., Laripour R; Social and Preventive Medicine Department, School of Medicine, AJA University of Medical Sciences, Tehran, Iran., Amoli AE; Trauma Research center, AJA university of Medical sciences, Tehran, Iran., Heidari R; Cancer Epidemiology Research Center (AJA-CERTC), AJA University of Medical Sciences, Tehran, Iran. r-Heidary@ajaums.ac.ir.; Medical Biotechnology Research Center, AJA University of Medical Sciences, Tehran, Iran. r-Heidary@ajaums.ac.ir., Chamanara M; Toxicology Research Center, AJA University of Medical Sciences, Tehran, Iran. chamanaramohsen@gmail.com.; Student research committee, AJA University of Medical Sciences, Tehran, Iran. chamanaramohsen@gmail.com.
Jazyk: angličtina
Zdroj: Molecular biology reports [Mol Biol Rep] 2024 Feb 23; Vol. 51 (1), pp. 325. Date of Electronic Publication: 2024 Feb 23.
DOI: 10.1007/s11033-024-09276-0
Abstrakt: Post-traumatic stress disorder (PTSD) is one of the most widespread and disabling psychiatric disorders among combat veterans. Substantial interindividual variability in susceptibility to PTSD suggests the presence of different risk factors for this disorder. Twin and family studies confirm genetic factors as important risk factors for PTSD. In addition to genetic factors, epigenetic factors, especially DNA methylation, can be considered as a potential mechanism in changing the risk of PTSD. So far, many genetic and epigenetic association studies have been conducted in relation to PTSD. In genetic studies, many single nucleotide polymorphisms have been identified as PTSD risk factors. Meanwhile, the variations in catecholamines-related genes, serotonin transporter and receptors, brain-derived neurotrophic factor, inflammatory factors, and apolipoprotein E are the most prominent candidates. CpG methylation in the upstream regions of many genes is also considered a PTSD risk factor. Accurate identification of genetic and epigenetic changes associated with PTSD can lead to the presentation of suitable biomarkers for susceptible individuals to this disorder. This study aimed to delineate prominent genetic variations and epigenetic changes associated with post-traumatic stress disorder in military veterans who have experienced combat, focusing on genetic and epigenetic association studies.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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