Interactions Between the Ubiquitin-Proteasome System, Nrf2, and the Cannabinoidome as Protective Strategies to Combat Neurodegeneration: Review on Experimental Evidence.

Autor: Monsalvo-Maraver LA; Facultad de Ciencias, Universidad Nacional Autónoma de México, Av. Universidad 3000, C.U. Coyoacán, 04510, Mexico City, Mexico. luismonsalvo@ciencias.unam.mx., Ovalle-Noguez EA; Facultad de Ciencias, Universidad Nacional Autónoma de México, Av. Universidad 3000, C.U. Coyoacán, 04510, Mexico City, Mexico., Nava-Osorio J; Facultad de Ciencias, Universidad Nacional Autónoma de México, Av. Universidad 3000, C.U. Coyoacán, 04510, Mexico City, Mexico., Maya-López M; Facultad de Ciencias, Universidad Nacional Autónoma de México, Av. Universidad 3000, C.U. Coyoacán, 04510, Mexico City, Mexico.; Doctorado en Ciencias Biológicas y de La Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City, Mexico., Rangel-López E; Instituto Nacional de Neurología y Neurocirugía, S.S.A., Mexico City, Mexico., Túnez I; Instituto de Investigaciones Biomédicas Maimonides de Córdoba (IMIBIC), Departamento de Bioquímica y Biología Molecular, Facultad de Medicina y Enfermería, Universidad de Córdoba, Red Española de Excelencia en Estimulación Cerebral (REDESTIM), Córdoba, Spain., Tinkov AA; IM Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.; Yaroslavl State University, Yaroslavl, Russia., Tizabi Y; Department of Pharmacology, Howard University College of Medicine, Washington, DC, USA., Aschner M; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA., Santamaría A; Facultad de Ciencias, Universidad Nacional Autónoma de México, Av. Universidad 3000, C.U. Coyoacán, 04510, Mexico City, Mexico. absada@yahoo.com.
Jazyk: angličtina
Zdroj: Neurotoxicity research [Neurotox Res] 2024 Feb 23; Vol. 42 (2), pp. 18. Date of Electronic Publication: 2024 Feb 23.
DOI: 10.1007/s12640-024-00694-3
Abstrakt: Neurodegenerative disorders are chronic brain diseases that affect humans worldwide. Although many different factors are thought to be involved in the pathogenesis of these disorders, alterations in several key elements such as the ubiquitin-proteasome system (UPS), the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, and the endocannabinoid system (ECS or endocannabinoidome) have been implicated in their etiology. Impairment of these elements has been linked to the origin and progression of neurodegenerative disorders, while their potentiation is thought to promote neuronal survival and overall neuroprotection, as proved with several experimental models. These key neuroprotective pathways can interact and indirectly activate each other. In this review, we summarize the neuroprotective potential of the UPS, ECS, and Nrf2 signaling, both separately and combined, pinpointing their role as a potential therapeutic approach against several hallmarks of neurodegeneration.
(© 2024. The Author(s).)
Databáze: MEDLINE
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