Determinants of Immunovirological Response among Children and Adolescents Living with HIV-1 in the Central Region of Cameroon.

Autor:	Dobseu Soudebto RS; 'Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé P.O. Box 3077, Cameroon., Fokam J; 'Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé P.O. Box 3077, Cameroon.; Faculty of Medicine and Biomedical Sciences (FMSB), University of Yaoundé I, Yaoundé P.O. Box 3077, Cameroon.; Faculty of Health Sciences, University of Buea, Buea P.O. Box 63, Cameroon., Kamgaing N; 'Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé P.O. Box 3077, Cameroon.; Faculty of Medicine and Biomedical Sciences (FMSB), University of Yaoundé I, Yaoundé P.O. Box 3077, Cameroon.; Department of Gynecology Obstetrics, University Teaching Hospital (CHU), Yaoundé P.O. Box 3077, Cameroon., Fainguem N; 'Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé P.O. Box 3077, Cameroon., Ngoufack Jagni Semengue E; 'Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé P.O. Box 3077, Cameroon., Tommo Tchouaket MC; 'Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé P.O. Box 3077, Cameroon., Kamgaing R; 'Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé P.O. Box 3077, Cameroon., Nanfack A; 'Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé P.O. Box 3077, Cameroon., Bouba Y; Microbiology and Clinical Microbiology, UniCamillus-Saint Camillus International University of Health Sciences, 00131 Rome, Italy., Yimga J; 'Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé P.O. Box 3077, Cameroon., Chenwi Ambe C; 'Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé P.O. Box 3077, Cameroon.; Department of Experimental Medicine, Faculty of Medicine and Surgery, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy., Gouissi H; 'Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé P.O. Box 3077, Cameroon.; Faculty of Medicine and Biomedical Sciences (FMSB), University of Yaoundé I, Yaoundé P.O. Box 3077, Cameroon., Efakika Gabisa J; 'Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé P.O. Box 3077, Cameroon., Nnomo Zam K; 'Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé P.O. Box 3077, Cameroon., Nka AD; 'Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé P.O. Box 3077, Cameroon., Sosso SM; 'Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé P.O. Box 3077, Cameroon., Halle-Ekane GE; Faculty of Health Sciences, University of Buea, Buea P.O. Box 63, Cameroon., Okomo MC; Faculty of Medicine and Biomedical Sciences (FMSB), University of Yaoundé I, Yaoundé P.O. Box 3077, Cameroon.; National Public Health Laboratory, Yaoundé P.O. Box 3077, Cameroon., Ndjolo A; 'Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaoundé P.O. Box 3077, Cameroon.; Faculty of Medicine and Biomedical Sciences (FMSB), University of Yaoundé I, Yaoundé P.O. Box 3077, Cameroon.
Jazyk:	angličtina
Zdroj:	Tropical medicine and infectious disease [Trop Med Infect Dis] 2024 Feb 14; Vol. 9 (2). Date of Electronic Publication: 2024 Feb 14.
DOI:	10.3390/tropicalmed9020048
Abstrakt:	About 90% of new HIV-1 infections in children occur in sub-Saharan Africa, where treatment monitoring remains suboptimal. We sought to ascertain factors associated with immunovirological responses among an ART-experienced paediatric population in Cameroon. A laboratory-based and analytical study was conducted from January 2017 throughout December 2020 wherein plasma viral load (PVL) analyses and CD4 cell counts were performed. Viral suppression (VS) was defined as PVL < 1000 copies/mL and immunological failure (IF) as CD4 < 500 cells/µL for participants ≤5 years and CD4 < 250 cells/µL for those >5 years; p < 0.05 was considered statistically significant. Overall, 272 participants were enrolled (median age: 13 [9-15.5] years; 54% males); median ART duration 7 [3-10] years. Globally, VS was achieved in 54.41%. VS was 56.96% in urban versus 40.48% in rural areas ( p = 0.04). IF was 22.43%, with 15.79% among participants ≤5 years and 22.92% among those >5 years ( p = 0.66). IF was 20.43% in urban versus 33.33% in rural areas ( p = 0.10). Following ART, IF was 25.82% on first-line (non-nucleoside reverse transcriptase inhibitors; NNRTI-based) versus 10.17% on second-line (protease inhibitor-based) regimens ( p = 0.01). Interestingly, IF was 7.43% among virally suppressed versus 40.32% among virally unsuppressed participants ( p < 0.0001). A low VS indicates major challenges in achieving AIDS' elimination in this paediatric population, especially in rural settings and poor immune statuses. Scaling up NNRTI-sparing regimens alongside close monitoring would ensure optimal therapeutic outcomes.
Databáze:	MEDLINE
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