Structure-activity studies on methoxy-substituted phenylisopropylamines using drug discrimination methodology.

Autor: Glennon RA, Young R, Hauck AE
Jazyk: angličtina
Zdroj: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 1985 May; Vol. 22 (5), pp. 723-9.
DOI: 10.1016/0091-3057(85)90520-9
Abstrakt: Eighteen rats were trained to discriminate 1.0 mg/kg of (+)-amphetamine sulfate from saline in a two-lever operant procedure. Once responding was stable, these animals were administered various doses of sixteen different methoxy-substituted phenylisopropylamines in tests of stimulus generalization. Of three possible mono-methoxyphenylisopropylamines, all three produced amphetamine-appropriate responding, but none was as potent as racemic amphetamine. The amphetamine-stimulus did not completely generalize to any of the di- or tri-methoxyphenylisopropylamines.
Databáze: MEDLINE