| Autor: |
Ghozzi M; Laboratroy of Immunology, Farhat Hached University Hospital, Rue Ibn El Jazzar Sousse Tunisie., Mechi F; Immunologie, University of Monastir, Tunisia., Salem AB; Immunologie, University of Monastir, Tunisia., El Ahmer I; Immunologie, University of Monastir, Tunisia., Mbarki DR; Hematology, Hôpital Sahloul, Tunisia., Melayah S; Laboratroy of Immunology, Farhat Hached University Hospital, Rue Ibn El Jazzar Sousse Tunisie., Mankai A; Laboratroy of Immunology, Farhat Hached University Hospital, Rue Ibn El Jazzar Sousse Tunisie., Ghedira I; Laboratroy of Immunology, Farhat Hached University Hospital, Rue Ibn El Jazzar Sousse Tunisie. |
| Abstrakt: |
Celiac disease (CD) and rheumathoid arthritis (RA) are both multi-factorial chronic inflammatory auto-immune diseases. In this retrospective study, we determined the frequency of CD in patients with RA using IgA anti-endomysial antibodies (EmA) and tried to explain this association. Indirect immunofluorescence on human umbilical cord was used to detect EmA in 215 patients with seropositive RA collected over a 4-year-period. Two thousand and five hundred healthy blood donors (HBD) served as control group. Among the 215 patients with RA, 12 (9 females) were found positive for EmA while only 7 were positive for EmA in control group, EmA are significantly more frequent in RA patients than in HBD (5.58% vs. 0.28%, p < 10-6; 95% CI [8.21-54.01]; odds ratio: 21.05). In RA patients, the frequency of EmA was not statistically different between males and females. The frequency of EmA was significantly higher in female patients than in healthy females (5.32% vs. 0.40%, p < 10-3). Patients with RA can be considered as a high-risk group for CD based on the high frequency of EmA positivity observed in our study. |
