Effectiveness of Head-and-Neck Molecular Imaging Reporting and Data System Criterion in Head-and-Neck Squamous Cell Carcinoma PostConcurrent Chemoradiotherapy.

Autor: Gupta M; Department of Nuclear Medicine, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Jajodia A; Department of Radiology, Juravinski Hospital, McMaster University, Hamilton, Canada., Ahlawat P; Department of Radiotherapy, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Gairola M; Department of Radiotherapy, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Agarwal M; Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Goyal S; Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Mehta P; Department of Nuclear Medicine, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Choudhury PS; Department of Nuclear Medicine, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
Jazyk: angličtina
Zdroj: Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India [Indian J Nucl Med] 2023 Oct-Dec; Vol. 38 (4), pp. 334-339. Date of Electronic Publication: 2023 Dec 20.
DOI: 10.4103/ijnm.ijnm_23_23
Abstrakt: Purpose: Postconcurrent chemoradiotherapy (CRT) response assessment has been challenging in locally advanced head-and-neck squamous cell carcinoma (LA-HNSCC) due to prevailing postradiation changes. Molecular response methods have been encouraging, although further clarifications and validations were needed. We tested the effectiveness of a proposed semi-quantitative molecular response criterion in these patients.
Materials and Methods: Two subspecialty-trained physicians evaluated 18 F-fluorodeoxyglucose positron emission tomography/computed tomography of LA-HNSCC patients ( n = 83) post 3 months CRT using a five points Head and Neck Molecular Imaging-Reporting and Data System (HAN-MI-RADS) criterion. Where available, histopathology examination with clinical and imaging interpretation was taken as a reference for the disease. A diagnostic accuracy comparison was done with the existing Hopkins score. Further effectiveness was analyzed with disease-free survival (DFI) and overall survival (OS).
Results: Metastasis was developed in 11/83 patients at 3 months of evaluation. Of 72 patients, 39, 2, and 31 patients had a complete response, equivocal response, and partial response as per HAN-MI-RADS. Per patient sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for predicting loco-regional disease up to 1 and 2 years was 93.3%, 92.5%, 90.3%, 94.9%, 92.9%, and 84.9%, 91.9%, 90.3%, 87.2%, and 88.6% respectively. One year and two years DFI for each HAN-MI-RADS score showed a statistically significant difference while it was not for OS. The receiver operating characteristic curve analysis showed significantly better outcome predictability of HAN-MI-RADS (area under the curve [AUC] 0.884) than Hopkins (AUC 0.699).
Conclusions: A five points HAN-MI-RADS criterion was found promising for response assessment with less equivocal results and statistically significant higher AUC than Hopkins for loco-regional recurrence prediction.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2023 Indian Journal of Nuclear Medicine.)
Databáze: MEDLINE
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