Metabolomic profiling reveals key metabolites associated with hypertension progression.

Autor:	Al Ashmar S; Department of Basic Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar., Anwardeen NR; Biomedical Research Center, Qatar University, Doha, Qatar., Anlar GG; Department of Basic Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar., Pedersen S; Department of Basic Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar., Elrayess MA; Department of Basic Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar.; Biomedical Research Center, Qatar University, Doha, Qatar., Zeidan A; Department of Basic Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar.
Jazyk:	angličtina
Zdroj:	Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2024 Feb 08; Vol. 11, pp. 1284114. Date of Electronic Publication: 2024 Feb 08 (Print Publication: 2024).
DOI:	10.3389/fcvm.2024.1284114
Abstrakt:	Introduction: Pre-hypertension is a prevalent condition among the adult population worldwide. It is characterized by asymptomatic elevations in blood pressure beyond normal levels but not yet reaching the threshold for hypertension. If left uncontrolled, pre-hypertension can progress to hypertension, thereby increasing the risk of serious complications such as heart disease, stroke, kidney damage, and others. Objective: The precise mechanisms driving the progression of hypertension remain unknown. Thus, identifying the metabolic changes associated with this condition can provide valuable insights into potential markers or pathways implicated in the development of hypertension. Methods: In this study, we utilized untargeted metabolomics profiling, which examines over 1,000 metabolites to identify novel metabolites contributing to the progression from pre-hypertension to hypertension. Data were collected from 323 participants through Qatar Biobank. Results: By comparing metabolic profiles between pre-hypertensive, hypertensive and normotensive individuals, six metabolites including stearidonate, hexadecadienoate, N6-carbamoylthreonyladenosine, 9 and 13-S-hydroxyoctadecadienoic acid (HODE), 2,3-dihydroxy-5-methylthio- 4-pentenoate (DMTPA), and linolenate were found to be associated with increased risk of hypertension, in both discovery and validation cohorts. Moreover, these metabolites showed a significant diagnostic performance with area under curve >0.7. Conclusion: These findings suggest possible biomarkers that can predict the risk of progression from pre-hypertension to hypertension. This will aid in early detection, diagnosis, and management of this disease as well as its associated complications. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2024 Al Ashmar, Anwardeen, Anlar, Pedersen, Elrayess and Zeidan.)
Databáze:	MEDLINE
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