Factors Associated with Parametrial Involvement in Endometrial Carcinoma in Patients Treated with Radical Hysterectomy.

Autor:	Barquet-Muñoz S; Programa de Maestría y Doctorado en Ciencias Médicas, Odontológicas y de la Salud, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico.; Department of Gynecology, Instituto Nacional de Cancerologia, Ciudad de Mexico, Mexico., Bandala-Jaques A; Biomedical Cancer Research Unit, Instituto Nacional de Cancerologia, Ciudad de Mexico, Mexico., Perez-Montiel MD; Department of Pathology, Instituto Nacional de Cancerologia, Ciudad de Mexico, Mexico., Prada D; Basic Research, Instituto Nacional de Cancerologia, Ciudad de Mexico, Mexico., Martínez-Flores M; Clinical Research, Instituto Nacional de Cancerologia, Ciudad de Mexico, Mexico., Salcedo-Hernández RA; Department of Gynecology, Instituto Nacional de Cancerologia, Ciudad de Mexico, Mexico., Pérez-Plasencia C; Biomedical Cancer Research Unit, Instituto Nacional de Cancerologia, Ciudad de Mexico, Mexico., Gonzalez-Enciso A; Department of Gynecology, Instituto Nacional de Cancerologia, Ciudad de Mexico, Mexico., Leon DC; Direction of Research, Instituto Nacional de Cancerologia, Ciudad de Mexico, Mexico.
Jazyk:	angličtina
Zdroj:	International journal of surgical pathology [Int J Surg Pathol] 2024 Oct; Vol. 32 (7), pp. 1241-1247. Date of Electronic Publication: 2024 Feb 22.
DOI:	10.1177/10668969231225773
Abstrakt:	Introduction: Describe factors associated with parametrial involvement, and how these factors modify the prognosis of patients with endometrial carcinoma treated with radical hysterectomy. Methods: Observational study in which categorized patients according to those with and without parametrial involvement. A descriptive analysis and comparative analysis were performed for associations between parametrial spread and clinical, surgical, and pathology variables. Results: We analyzed 85 patients, which 18 (21%) had parametrial involvement. Pathology factors associated with parametrial involvement were the endometrioid subtype, grade 3, and variants of poor prognosis (odds ratio (OR) 3.41, 95% CI 1.09-10.64; P  = 0.035), myometrial invasion of over 50% (OR 7.76, 95% CI 1.65-36.44; P  = 0.009), serosal involvement (OR 17.07, 95% CI 3.87-75.35; P  < 0.001), ovarian metastasis (OR 5.15, 95% CI 1.36-19.46; P  = 0.016), positive peritoneal cytology (OR 3.9, 95% CI 1.04-14.77; P  = 0.044), and lymph node metastasis (OR 3.4; 95% CI 1.16-9.97; P  = 0.026). Five-year disease-free survival was 74% (95% CI 57.4-85.4) for the group without parametrial spread and 50.8% (95% CI 22.7-73.4) for the group with parametrial spread ( P  = 0.001). Similarly, 5-year overall survival was 85.2% (95% CI 67.9-93.6) for the group without parametrial spread and 47.5% (95% CI 8.1-80.2) for the group with parametrial spread ( P  = 0.002). Conclusion: Factors associated with parametrial involvement were histologies of poor prognosis, tumors affecting uterine serosa, cervix, or spread beyond the uterus. Additionally, parametrial involvement directly affects prognosis by reducing overall survival, disease-free survival and increasing odds for recurrence. Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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