Effect of Aerobic Exercise and Time-Restricted Feeding on Metabolic Markers and Circadian Rhythm in Mice Fed with the High-Fat Diet.

Autor: Raza GS; Research Unit of Biomedicine and Internal Medicine, Medical Research Center, Faculty of Medicine, Biocenter of Oulu, University of Oulu, Aapistie 5, Oulu, 90220, Finland., Kaya Y; Faculty of Health Sciences, Department of Nutrition and Dietetics, Istanbul Kent University, Istanbul, 34406, Turkey., Stenbäck V; Research Unit of Biomedicine and Internal Medicine, Medical Research Center, Faculty of Medicine, Biocenter of Oulu, University of Oulu, Aapistie 5, Oulu, 90220, Finland., Sharma R; Research Unit of Biomedicine and Internal Medicine, Medical Research Center, Faculty of Medicine, Biocenter of Oulu, University of Oulu, Aapistie 5, Oulu, 90220, Finland., Sodum N; Research Unit of Biomedicine and Internal Medicine, Medical Research Center, Faculty of Medicine, Biocenter of Oulu, University of Oulu, Aapistie 5, Oulu, 90220, Finland., Mutt SJ; Department of Medical Cell Biology, Science for Life Laboratory, Uppsala University, Uppsala, 75123, Sweden., Gagnon DD; Faculty of Sports and Health Sciences, University of Jyväskylä, Seminaarinkatu 15, Jyväskylä, 40014, Finland.; Clinic for Sports and Exercise Medicine, Department of Sports and Exercise Medicine, Faculty of Medicine, University of Helsinki Mäkelänkatu, Helsinki, 00550, Finland., Tulppo M; Research Unit of Biomedicine and Internal Medicine, Medical Research Center, Faculty of Medicine, Biocenter of Oulu, University of Oulu, Aapistie 5, Oulu, 90220, Finland., Järvelin MR; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, SW72AZ, UK., Herzig KH; Research Unit of Biomedicine and Internal Medicine, Medical Research Center, Faculty of Medicine, Biocenter of Oulu, University of Oulu, Aapistie 5, Oulu, 90220, Finland.; Pediatric Gastroenterology and Metabolic Diseases, Pediatric Institute, Poznan University of Medical Sciences, Poznań, 60-572, Poland., Mäkelä KA; Research Unit of Biomedicine and Internal Medicine, Medical Research Center, Faculty of Medicine, Biocenter of Oulu, University of Oulu, Aapistie 5, Oulu, 90220, Finland.
Jazyk: angličtina
Zdroj: Molecular nutrition & food research [Mol Nutr Food Res] 2024 Mar; Vol. 68 (5), pp. e2300465. Date of Electronic Publication: 2024 Feb 22.
DOI: 10.1002/mnfr.202300465
Abstrakt: Scope: Diet and exercise are significant players in obesity and metabolic diseases. Time-restricted feeding (tRF) has been shown to improve metabolic responses by regulating circadian clocks but whether it acts synergically with exercise remains unknown. It is hypothesized that forced exercise alone or combined with tRF alleviates obesity and its metabolic complications.
Methods and Results: Male C57bl6 mice are fed with high-fat or a control diet for 12 weeks either ad libitum or tRF for 10 h during their active period. High-fat diet (HFD)-fed mice are divided into exercise (treadmill for 1 h at 12 m min -1 alternate days for 9 weeks and 16 m min -1 daily for the following 3 weeks) and non-exercise groups. tRF and tRF-Ex significantly decreased body weight, food intake, and plasma lipids, and improved glucose tolerance. However, exercise reduced only body weight and plasma lipids. tRF and tRF-Ex significantly downregulated Fasn, Hmgcr, and Srebp1c, while exercise only Hmgcr. HFD feeding disrupted clock genes, but exercise, tRF, and tRF-Ex coordinated the circadian clock genes Bmal1, Per2, and Rev-Erbα in the liver, adipose tissue, and skeletal muscles.
Conclusion: HFD feeding disrupted clock genes in the peripheral organs while exercise, tRF, and their combination restored clock genes and improved metabolic consequences induced by high-fat diet feeding.
(© 2024 The Authors. Molecular Nutrition & Food Research published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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