Synergistic chemo-photothermal therapy using gold nanorods supported on thiol-functionalized mesoporous silica for lung cancer treatment.

Autor: Deinavizadeh M; Department of Chemistry, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran., Kiasat AR; Department of Chemistry, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran. akiasat@scu.ac.ir.; Petroleum Geology and Geochemistry Research Center (PGGRC), Shahid Chamran University of Ahvaz, Ahvaz, Iran. akiasat@scu.ac.ir., Shafiei M; Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran., Sabaeian M; Department of Physics, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.; Center for Research On Laser and Plasma, Shahid Chamran University of Ahvaz, Ahvaz, Iran., Mirzajani R; Department of Chemistry, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran., Zahraei SM; Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran., Khalili F; Department of Chemistry, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran., Shao M; Department of Otorhinolaryngology, The Second Affiliated Hospital of Shanghai University, Wenzhou Central Hospital, Wenzhou, China., Wu A; Department of Orthopaedics, Key Laboratory of Structural Malformations in Children of Zhejiang Province, Key Laboratory of Orthopaedics of Zhejiang Province, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China., Makvandi P; Centre of Research Impact and Outcome, Chitkara University, Rajpura, 140401, Punjab, India. pooyanmakvandi@gmail.com.; Department of Biomaterials, Saveetha Dental College and Hospitals, SIMATS, Saveetha University, Saveetha University, Chennai, 600077, India. pooyanmakvandi@gmail.com., Hooshmand N; Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA. nhooshmand3@gatech.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Feb 22; Vol. 14 (1), pp. 4373. Date of Electronic Publication: 2024 Feb 22.
DOI: 10.1038/s41598-024-54778-3
Abstrakt: Cancer therapy necessitates the development of novel and effective treatment modalities to combat the complexity of this disease. In this project, we propose a synergistic approach by combining chemo-photothermal treatment using gold nanorods (AuNRs) supported on thiol-functionalized mesoporous silica, offering a promising solution for enhanced lung cancer therapy. To begin, mesoporous MCM-41 was synthesized using a surfactant-templated sol-gel method, chosen for its desirable porous structure, excellent biocompatibility, and non-toxic properties. Further, thiol-functionalized MCM-41 was achieved through a simple grafting process, enabling the subsequent synthesis of AuNRs supported on thiol-functionalized MCM-41 (AuNR@S-MCM-41) via a gold-thiol interaction. The nanocomposite was then loaded with the anticancer drug doxorubicin (DOX), resulting in AuNR@S-MCM-41-DOX. Remarkably, the nanocomposite exhibited pH/NIR dual-responsive drug release behaviors, facilitating targeted drug delivery. In addition, it demonstrated exceptional biocompatibility and efficient internalization into A549 lung cancer cells. Notably, the combined photothermal-chemo therapy by AuNR@S-MCM-41-DOX exhibited superior efficacy in killing cancer cells compared to single chemo- or photothermal therapies. This study showcases the potential of the AuNR@S-MCM-41-DOX nanocomposite as a promising candidate for combined chemo-photothermal therapy in lung cancer treatment. The innovative integration of gold nanorods, thiol-functionalized mesoporous silica, and pH/NIR dual-responsive drug release provides a comprehensive and effective therapeutic approach for improved outcomes in lung cancer therapy. Future advancements based on this strategy hold promise for addressing the challenges posed by cancer and transforming patient care.
(© 2024. The Author(s).)
Databáze: MEDLINE
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