MIRD Pamphlet No. 29: MIRDy90-A 90 Y Research Microsphere Dosimetry Tool.
| Autor: | Marquis H; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York., Ocampo Ramos JC; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York., Carter LM; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York., Zanzonico P; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York., Bolch WE; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida; and., Laforest R; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri., Kesner AL; Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York; kesnera@mskcc.org. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2024 Feb 22. Date of Electronic Publication: 2024 Feb 22. |
| DOI: | 10.2967/jnumed.123.266743 |
| Abstrakt: | 90 Y-microsphere radioembolization has become a well-established treatment option for liver malignancies and is one of the first U.S. Food and Drug Administration-approved unsealed radionuclide brachytherapy devices to incorporate dosimetry-based treatment planning. Several different mathematical models are used to calculate the patient-specific prescribed activity of 90 Y, namely, body surface area (SIR-Spheres only), MIRD single compartment, and MIRD dual compartment (partition). Under the auspices of the MIRDsoft initiative to develop community dosimetry software and tools, the body surface area, MIRD single-compartment, MIRD dual-compartment, and MIRD multicompartment models have been integrated into a MIRDy90 software worksheet. The worksheet was built in MS Excel to estimate and compare prescribed activities calculated via these respective models. The MIRDy90 software was validated against available tools for calculating 90 Y prescribed activity. The results of MIRDy90 calculations were compared with those obtained from vendor and community-developed tools, and the calculations agreed well. The MIRDy90 worksheet was developed to provide a vetted tool to better evaluate patient-specific prescribed activities calculated via different models, as well as model influences with respect to varying input parameters. MIRDy90 allows users to interact and visualize the results of various parameter combinations. Variables, equations, and calculations are described in the MIRDy90 documentation and articulated in the MIRDy90 worksheet. The worksheet is distributed as a free tool to build expertise within the medical physics community and create a vetted standard for model and variable management. (© 2024 by the Society of Nuclear Medicine and Molecular Imaging.) |
| Databáze: | MEDLINE |
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