Mechanistic modelling of amphibian body burdens after dermal uptake of pesticides from soil.

Autor: Mingo V; Corteva Agriscience, Munich, Bavaria, Germany. Electronic address: valentin.mingo@corteva.com., Foudoulakis M; Corteva Agriscience, Chalandri, Attica, Greece., Wheeler JR; Corteva Agriscience, Bergen op Zoom, North Brabant, the Netherlands.
Jazyk: angličtina
Zdroj: Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2024 Apr 01; Vol. 346, pp. 123614. Date of Electronic Publication: 2024 Feb 20.
DOI: 10.1016/j.envpol.2024.123614
Abstrakt: Amphibians are currently considered to be covered by pesticide Environmental Risk Assessment schemes by surrogacy assumptions of exposure and susceptibility based on typical laboratory test species such as fish, mammals, and birds. While multiple reviews have shown for this approach to be adequate in the case of aquatic stages, the same cannot be definitively stated for terrestrial stages. Concerns have risen that exposure of amphibians is likely to be highly influenced by dermal absorption, primarily due to the high permeability of their skin and the lack of a protective layer, such as fur or feathers. It is thus hypothesized that dermal uptake could be a significant route of exposure. Consequently, it is necessary to determine the relative importance of different exposure routes that might affect the integrated toxicity outcome for terrestrial amphibian life-stages. Here, a one-compartment Toxicokinetic model was derived and tested using a publicly available dataset containing relevant exposure and uptake information for juvenile anurans exposed to 13 different pesticides. Modelled body burdens were then compared to measured burdens for a total of 815 individuals. Overall, a good concordance between modelled and measured values was observed, with the predicted and measured body burdens differing by a factor of 2 on average (overall R 2 of 0.80 and correlation coefficient of 0.89), suggesting good predictivity of the model. Accordingly, the model predicts realistic body burdens for a variety of frog and toad species, and overall, for anurans. As the model includes rehydration (implicit in the evaluated studies) but currently does not account for metabolism, it can be seen as a worst-case assessment. We suggest toxicokinetic models, such as the one here presented, could be used to characterize dermal exposure in amphibians, screen for pesticides of concern, and prioritize risk assessment efforts, whilst reducing the need for de novo vertebrate testing.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Valentin Mingo reports a relationship with Corteva Agriscience that includes: employment. James R. Wheeler reports a relationship with Corteva Agriscience that includes: employment. Manousos Foudoulakis reports a relationship with Corteva Agriscience that includes: employment. VM, JRW and MF are full time employees for Corteva Agriscience. The authors declare no conflicts of interest. We are grateful for the thoughtful comments of Vince Kramer, John Marton and Marina Lauck, that greatly improved the manuscript. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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