A versatile upconversion-based multimode lateral flow platform for rapid and ultrasensitive detection of microRNA towards health monitoring.
Autor: | Chen C; Department of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun, 130021, PR China., Hu S; State Key Laboratory on Integrated Optoelectronics, Collage of Electronic Science and Engineering, Jilin University, Changchun, 130021, PR China., Tian L; Department of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun, 130021, PR China., Qi M; Department of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun, 130021, PR China., Chang Z; Key Laboratory of Bionic Engineering, Ministry of Education, College of Biological and Agricultural Engineering, Jilin University, Changchun, 130022, PR China., Li L; State Key Laboratory of Superhard Materials, Collage of Physics, Jilin University, Changchun, 130021, PR China. Electronic address: lliang@jlu.edu.cn., Wang L; Department of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun, 130021, PR China. Electronic address: wanglin1982@jlu.edu.cn., Dong B; State Key Laboratory on Integrated Optoelectronics, Collage of Electronic Science and Engineering, Jilin University, Changchun, 130021, PR China. Electronic address: dongb@jlu.edu.cn. |
---|---|
Jazyk: | angličtina |
Zdroj: | Biosensors & bioelectronics [Biosens Bioelectron] 2024 May 15; Vol. 252, pp. 116135. Date of Electronic Publication: 2024 Feb 16. |
DOI: | 10.1016/j.bios.2024.116135 |
Abstrakt: | MicroRNAs are small single-stranded RNA molecules associated with gene expression and immune response, suggesting their potential as biomarkers for health monitoring. Herein, we designed a novel upconversion-based multimode lateral flow assay (LFA) system to detect microRNAs in body fluids by simultaneously producing three unique signals within a detection strip. The core-shell Au-DTNB@Ag nanoparticles act as both the Raman reporters and acceptors, quenching fluorescence from upconversion nanoparticles (UCNPs, NaYF Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
Databáze: | MEDLINE |
Externí odkaz: |