Immunophenotypic predictors of influenza vaccine immunogenicity in pediatric hematopoietic cell transplant recipients.

Autor:	Amarin JZ; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN.; Epidemiology Doctoral Program, School of Medicine, Vanderbilt University, Nashville, TN., Dulek DE; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN., Simmons J; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Hayek H; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN., Chappell JD; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN., Nochowicz CH; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Kitko CL; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN., Schuster JE; Department of Pediatrics, Children's Mercy Kansas City, Kansas City, MO., Muñoz FM; Division of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX.; Department of Molecular Virology and Microbiology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX., Bocchini CE; Division of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX., Moulton EA; Division of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX., Coffin SE; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Freedman JL; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Ardura MI; Division of Infectious Diseases and Host Defense Program, Nationwide Children's Hospital, Columbus, OH.; Department of Pediatrics, The Ohio State University, Columbus, OH., Wattier RL; Department of Pediatrics, University of California San Francisco and Benioff Children's Hospital, San Francisco, CA., Maron G; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN., Grimley M; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Paulsen G; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Danziger-Isakov L; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Carpenter PA; Department of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, WA., Englund JA; Department of Pediatrics, University of Washington and Seattle Children's Research Institute, Seattle, WA., Halasa NB; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN., Spieker AJ; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN., Kalams SA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN.
Jazyk:	angličtina
Zdroj:	Blood advances [Blood Adv] 2024 Apr 23; Vol. 8 (8), pp. 1880-1892.
DOI:	10.1182/bloodadvances.2023012118
Abstrakt:	Abstract: Pediatric hematopoietic cell transplant (HCT) recipients exhibit poor serologic responses to influenza vaccination early after transplant. To facilitate the optimization of influenza vaccination timing, we sought to identify B- and T-cell subpopulations associated with influenza vaccine immunogenicity in this population. We used mass cytometry to phenotype peripheral blood mononuclear cells collected from pediatric HCT recipients enrolled in a multicenter influenza vaccine trial comparing high- and standard-dose formulations over 3 influenza seasons (2016-2019). We fit linear regression models to estimate relationships between immune cell subpopulation numbers before vaccination and prevaccination to postvaccination geometric mean fold rises in antigen-specific (A/H3N2, A/H1N1, and B/Victoria) serum hemagglutination inhibition antibody titers (28-42 days, and ∼6 months after 2 doses). For cell subpopulations identified as predictive of a response to all 3 antigens, we conducted a sensitivity analysis including time after transplant as an additional covariate. Among 156 HCT recipients, we identified 33 distinct immune cell subpopulations; 7 significantly predicted responses to all 3 antigens 28 to 42 days after a 2-dose vaccine series, irrespective of vaccine dose. We also found evidence that baseline absolute numbers of naïve B cells, naïve CD4+ T cells, and circulating T follicular helper cells predicted peak and sustained vaccine-induced titers irrespective of dose or timing of posttransplant vaccine administration. In conclusion, several B- and T-cell subpopulations predicted influenza vaccine immunogenicity in pediatric HCT recipients. This study provides insights into the immune determinants of vaccine responses and may help guide the development of tailored vaccination strategies for this vulnerable population. (© 2024 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.)
Databáze:	MEDLINE
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