Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome.

Autor: Walitt B; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA., Singh K; National Heart, Lung and Blood Institute (NHLBI), Bethesda, MD, USA., LaMunion SR; National Institute of Diabetes, Digestion, and Kidney Disease (NIDDK), Bethesda, MD, USA., Hallett M; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA., Jacobson S; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA., Chen K; National Institute of Diabetes, Digestion, and Kidney Disease (NIDDK), Bethesda, MD, USA., Enose-Akahata Y; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA., Apps R; NIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, MD, USA., Barb JJ; NIH Clinical Center (CC), Bethesda, MD, USA., Bedard P; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA., Brychta RJ; National Institute of Diabetes, Digestion, and Kidney Disease (NIDDK), Bethesda, MD, USA., Buckley AW; National Institute of Mental Health (NIMH), Bethesda, MD, USA., Burbelo PD; National Institute of Dental and Craniofacial Research (NIDCR), Bethesda, MD, USA., Calco B; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA., Cathay B; Texas A&M School of Engineering Medicine, College Station, TX, USA., Chen L; Affiliated Hospital of North Sichuan Medical College, Sichuan, China., Chigurupati S; George Washington University Hospital, District of Columbia, Washington, DC, USA., Chen J; NIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, MD, USA., Cheung F; NIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, MD, USA., Chin LMK; NIH Clinical Center (CC), Bethesda, MD, USA., Coleman BW; Allegheny General Hospital, Pittsburgh, PA, USA., Courville AB; National Institute of Diabetes, Digestion, and Kidney Disease (NIDDK), Bethesda, MD, USA., Deming MS; NIH Clinical Center (CC), Bethesda, MD, USA., Drinkard B; NIH Clinical Center (CC), Bethesda, MD, USA., Feng LR; National Institute on Drug Abuse (NIDA), Bethesda, MD, USA., Ferrucci L; National Institute of Aging (NIA), Baltimore, MD, USA., Gabel SA; National Institute of Environmental Health Sciences (NIEHS), Chapel Hill, NC, USA., Gavin A; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA., Goldstein DS; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA., Hassanzadeh S; National Heart, Lung and Blood Institute (NHLBI), Bethesda, MD, USA., Horan SC; Sidney Kimmel Medical College, Philadelphia, PA, USA., Horovitz SG; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA., Johnson KR; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA., Govan AJ; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA., Knutson KM; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA., Kreskow JD; National Institute of Nursing Research (NINR), Bethesda, MD, USA., Levin M; National Heart, Lung and Blood Institute (NHLBI), Bethesda, MD, USA., Lyons JJ; National Institute of Allergy and Infectious Disease (NIAID), Bethesda, MD, USA., Madian N; National Center for Complementary and Integrative Health (NCCIH), Bethesda, MD, USA., Malik N; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA., Mammen AL; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD, USA., McCulloch JA; National Cancer Institute (NCI), Bethesda, MD, USA., McGurrin PM; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA., Milner JD; Columbia University Medical Center, New York, NY, USA., Moaddel R; National Institute of Aging (NIA), Baltimore, MD, USA., Mueller GA; National Institute of Environmental Health Sciences (NIEHS), Chapel Hill, NC, USA., Mukherjee A; NIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, MD, USA., Muñoz-Braceras S; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD, USA., Norato G; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA., Pak K; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD, USA., Pinal-Fernandez I; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD, USA., Popa T; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA., Reoma LB; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA., Sack MN; National Heart, Lung and Blood Institute (NHLBI), Bethesda, MD, USA., Safavi F; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.; National Institute of Allergy and Infectious Disease (NIAID), Bethesda, MD, USA., Saligan LN; National Institute of Nursing Research (NINR), Bethesda, MD, USA., Sellers BA; NIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, MD, USA., Sinclair S; National Institute of Mental Health (NIMH), Bethesda, MD, USA., Smith B; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA., Snow J; National Institute of Mental Health (NIMH), Bethesda, MD, USA., Solin S; NIH Clinical Center (CC), Bethesda, MD, USA., Stussman BJ; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA.; National Center for Complementary and Integrative Health (NCCIH), Bethesda, MD, USA., Trinchieri G; National Cancer Institute (NCI), Bethesda, MD, USA., Turner SA; NIH Clinical Center (CC), Bethesda, MD, USA., Vetter CS; University of Colorado School of Medicine, Boulder, CO, USA., Vial F; Clínica Alemana Universidad del Desarrollo, Santiago, Chile., Vizioli C; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA., Williams A; Oakland University William Beaumont School of Medicine, Rochester, NY, USA., Yang SB; NIH Clinical Center (CC), Bethesda, MD, USA., Nath A; National Institute of Neurological Diseases and Stroke (NINDS), Bethesda, MD, USA. Avindra.nath@nih.gov.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Feb 21; Vol. 15 (1), pp. 907. Date of Electronic Publication: 2024 Feb 21.
DOI: 10.1038/s41467-024-45107-3
Abstrakt: Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used rigorous criteria to recruit PI-ME/CFS participants with matched controls to conduct deep phenotyping. Among the many physical and cognitive complaints, one defining feature of PI-ME/CFS was an alteration of effort preference, rather than physical or central fatigue, due to dysfunction of integrative brain regions potentially associated with central catechol pathway dysregulation, with consequences on autonomic functioning and physical conditioning. Immune profiling suggested chronic antigenic stimulation with increase in naïve and decrease in switched memory B-cells. Alterations in gene expression profiles of peripheral blood mononuclear cells and metabolic pathways were consistent with cellular phenotypic studies and demonstrated differences according to sex. Together these clinical abnormalities and biomarker differences provide unique insight into the underlying pathophysiology of PI-ME/CFS, which may guide future intervention.
(© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze: MEDLINE
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