Vitamin D and follicular recruitment in the in vitro fertilization cycle.

Autor:	Antunes RA; Gynecology Department of the Clementino Fraga Filho University Hospital - Federal University of Rio de Janeiro - Rio de Janeiro - RJ, Brazil.; Fertipraxis - Human Reproduction Center, Rio de Janeiro - RJ, Brazil., Melo BML; Gynecology Department of the Clementino Fraga Filho University Hospital - Federal University of Rio de Janeiro - Rio de Janeiro - RJ, Brazil., Souza MDCB; Fertipraxis - Human Reproduction Center, Rio de Janeiro - RJ, Brazil., Souza MM; Fertipraxis - Human Reproduction Center, Rio de Janeiro - RJ, Brazil., Melo GPS; Gynecology Department of the Clementino Fraga Filho University Hospital - Federal University of Rio de Janeiro - Rio de Janeiro - RJ, Brazil., Jandre TFM; Gynecology Department of the Clementino Fraga Filho University Hospital - Federal University of Rio de Janeiro - Rio de Janeiro - RJ, Brazil., Mancebo ACA; Fertipraxis - Human Reproduction Center, Rio de Janeiro - RJ, Brazil., Conceição FL; Endocrinology Department of the Clementino Fraga Filho University Hospital Federal University of Rio de Janeiro - Rio de Janeiro - RJ, Brazil., Ortiga-Carvalho TM; Translational Endocrinology Lab of the Carlos Chagas Filho, Biophysics Institute - Federal University of Rio de Janeiro - Rio de Janeiro - RJ, Brazil.
Jazyk:	angličtina
Zdroj:	JBRA assisted reproduction [JBRA Assist Reprod] 2024 Jun 01; Vol. 28 (2), pp. 269-275. Date of Electronic Publication: 2024 Jun 01.
DOI:	10.5935/1518-0557.20240005
Abstrakt:	Objective: Vitamin D (VD) is a fat-soluble steroid hormone, synthesized by the skin, most known for its role in bone mineral balance. Vitamin D receptors (VDR) are also found in the female reproductive system, but their role remains unclear. The objective of this study was to analyze the relationship between serum vitamin D levels and the number of oocytes retrieved after ovarian stimulation. Methods: This is a retrospective study involving 267 patients undergoing in vitro fertilization (IVF) carried out in the Fertipraxis clinic, a private practice facility. The patients were initially divided into two groups according to their VD levels. Group 1 included 152 patients with VD levels < 30 ng/mL and group 2 had 115 patients with VD levels > 30 ng/mL. They were further analyzed and separated considering their age, anthropometric data, ovarian reserve, amount of gonadotropin used, and follicles obtained until trigger day. Results: In our analysis, there were no difference in the number of follicles and oocytes retrieved, nor in the number of mature oocytes obtained from patients with both vitamin D deficiency and sufficiency. Conclusions: The results of our study show no difference among number of follicles, oocytes retrieved and mature oocytes obtained after ovarian stimulation according to their vitamin D serum levels. Further higher-quality studies are needed to evaluate the possible roles of serum vitamin D levels in other stages of human fertilization process.
Databáze:	MEDLINE
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