Evaluating a novel 24-hour rest/activity rhythm marker of preclinical β-amyloid deposition.

Autor:	Spira AP; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Johns Hopkins Center on Aging and Health, Baltimore, MD, USA., Liu F; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Zipunnikov V; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Bilgel M; National Institute on Aging Intramural Research Program, Baltimore MD, USA., Rabinowitz JA; Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA., An Y; National Institute on Aging Intramural Research Program, Baltimore MD, USA., Di J; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Bai J; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Wanigatunga SK; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Wu MN; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA., Lucey BP; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Schrack JA; Johns Hopkins Center on Aging and Health, Baltimore, MD, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Wanigatunga AA; Johns Hopkins Center on Aging and Health, Baltimore, MD, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Rosenberg PB; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Simonsick EM; National Institute on Aging Intramural Research Program, Baltimore MD, USA., Walker KA; National Institute on Aging Intramural Research Program, Baltimore MD, USA., Ferrucci L; National Institute on Aging Intramural Research Program, Baltimore MD, USA., Resnick SM; National Institute on Aging Intramural Research Program, Baltimore MD, USA.
Jazyk:	angličtina
Zdroj:	Sleep [Sleep] 2024 May 10; Vol. 47 (5).
DOI:	10.1093/sleep/zsae037
Abstrakt:	Study Objectives: To compare sleep and 24-hour rest/activity rhythms (RARs) between cognitively normal older adults who are β-amyloid-positive (Aβ+) or Aβ- and replicate a novel time-of-day-specific difference between these groups identified in a previous exploratory study. Methods: We studied 82 cognitively normal participants from the Baltimore Longitudinal Study of Aging (aged 75.7 ± 8.5 years, 55% female, 76% white) with wrist actigraphy data and Aβ+ versus Aβ- status measured by [11C] Pittsburgh compound B positron emission tomography. RARs were calculated using epoch-level activity count data from actigraphy. We used novel, data-driven function-on-scalar regression analyses and standard RAR metrics to cross-sectionally compare RARs between 25 Aβ+ and 57 Aβ- participants. Results: Compared to Aβ- participants, Aβ+ participants had higher mean activity from 1:00 p.m. to 3:30 p.m. when using less conservative pointwise confidence intervals (CIs) and from 1:30 p.m. to 2:30 p.m. using more conservative, simultaneous CIs. Furthermore, Aβ+ participants had higher day-to-day variability in activity from 9:00 a.m. to 11:30 a.m. and lower variability from 1:30 p.m. to 4:00 p.m. and 7:30 p.m. to 10:30 p.m. according to pointwise CIs, and lower variability from 8:30 p.m. to 10:00 p.m. using simultaneous CIs. There were no Aβ-related differences in standard sleep or RAR metrics. Conclusions: Findings suggest Aβ+ older adults have higher, more stable day-to-day afternoon/evening activity than Aβ- older adults, potentially reflecting circadian dysfunction. Studies are needed to replicate our findings and determine whether these or other time-of-day-specific RAR features have utility as markers of preclinical Aβ deposition and if they predict clinical dementia and agitation in the afternoon/evening (i.e. "sundowning"). (© The Author(s) 2024. Published by Oxford University Press on behalf of Sleep Research Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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