Association of long COVID with health-related Quality of Life and Social Participation in Germany: Finding from an online-based cross-sectional survey.

Autor:	Schröder D; Department of General Practice, University Medical Center, Göttingen, Germany., Heinemann S; Department of General Practice, University Medical Center, Göttingen, Germany.; Department of Geriatrics, University Medical Center, Göttingen, Germany., Heesen G; Department of General Practice, University Medical Center, Göttingen, Germany., Hummers E; Department of General Practice, University Medical Center, Göttingen, Germany., Schmachtenberg T; Department of General Practice, University Medical Center, Göttingen, Germany.; Department of Rheumatology and Immunology, Hannover Medical School, Germany., Dopfer-Jablonka A; Department of Rheumatology and Immunology, Hannover Medical School, Germany.; German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, Germany., Vahldiek K; Department of Computer Science, Ostfalia University of Applied Sciences, Wolfenbuettel, Germany., Klawonn F; Department of Computer Science, Ostfalia University of Applied Sciences, Wolfenbuettel, Germany.; Biostatistics Group, Helmholtz Centre for Infection Research, Braunschweig, Germany., Klawitter S; Department of Computer Science, Ostfalia University of Applied Sciences, Wolfenbuettel, Germany., Steffens S; Department of Rheumatology and Immunology, Hannover Medical School, Germany.; Deans' Office, Curricular Development, Hannover Medical School, Germany., Mikuteit M; Department of Rheumatology and Immunology, Hannover Medical School, Germany.; Deans' Office, Curricular Development, Hannover Medical School, Germany., Niewolik J; Department of Rheumatology and Immunology, Hannover Medical School, Germany., Müller F; Department of General Practice, University Medical Center, Göttingen, Germany.; Department of Family Medicine, College of Human Medicine, Michigan State University, Grand Rapids, Michigan, USA.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2024 Feb 09; Vol. 10 (4), pp. e26130. Date of Electronic Publication: 2024 Feb 09 (Print Publication: 2024).
DOI:	10.1016/j.heliyon.2024.e26130
Abstrakt:	Purpose: This study aims to examine the health-related Quality of Life (hrQoL) and social participation in participants with Long COVID compared to participants without symptoms after COVID-19 and participants with no prior SARS-CoV-2 infection. Methods: A cross-sectional online survey was conducted in Germany. The non-random sample consists of participants 18 years or older. Participants were divided in three groups: Lg COVID with a prior SARS-CoV-2 infection and new or persistent symptoms 28 days after infection, ExCOVID with a prior SARS-CoV-2 infection and without new or persistent symptoms after 28 days, and NoCOVID when participants had no prior SARS-CoV-2 infection. EQ-5D-3L was used as hrQoL measure and the Index for the Assessment of Health Impairments (IMET) to reflect social participation. Descriptive and inferential statistics were performed. Results: A total of 3188 participants were included in the analysis (1421 Lg COVID, 260 ExCOVID, 1507 NoCOVID). Lg COVID was associated with the lowest EQ-5D-3L index values (p < 0.001), Visual Analogue Scale (VAS) scores (p < 0.001), and IMET (p < 0.001) scores followed by NoCOVID and ExCOVID. After adjusting for sociodemographic and medical conditions in a multivariable model Long COVID was still associated with lower hrQoL compared to NoCOVID (p < 0.001). About 10% of Lg COVID participants showed no health impairments in all EQ-5D dimensions while 51.1% of NoCOVID and 60% of ExCOVID participants showed no health impairments. Conclusion: This study highlights the impairments of persons with Long COVID on hrQoL and social participation compared to individuals without Long COVID in Germany. Trial Registration: German Clinical Trial Registry, DRKS00026007. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.)
Databáze:	MEDLINE
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