Environmental enrichment promotes adaptive responding during tests of behavioral regulation in male heterogeneous stock rats.

Autor: Ishiwari K; Clinical and Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA.; Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, USA., King CP; Clinical and Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA.; Department of Psychology, University at Buffalo, Buffalo, NY, 14260, USA., Martin CD; Clinical and Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA., Tripi JA; Department of Psychology, University at Buffalo, Buffalo, NY, 14260, USA., George AM; Clinical and Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA., Lamparelli AC; Department of Psychology, University at Buffalo, Buffalo, NY, 14260, USA., Chitre AS; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Polesskaya O; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Richards JB; Clinical and Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA., Solberg Woods LC; Department of Internal Medicine, Molecular Medicine, Center on Diabetes, Obesity and Metabolism, Wake Forest School of Medicine, Winston-Salem, NC, USA., Gancarz AM; Department of Psychology, California State University, Bakersfield, CA, USA., Palmer AA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Dietz DM; Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, USA., Mitchell SH; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA.; Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA.; Oregon Institute for Occupational Health Sciences, Oregon Health & Science University, Portland, OR, USA., Meyer PJ; Department of Psychology, University at Buffalo, Buffalo, NY, 14260, USA. pmeyer@buffalo.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Feb 20; Vol. 14 (1), pp. 4182. Date of Electronic Publication: 2024 Feb 20.
DOI: 10.1038/s41598-024-53943-y
Abstrakt: Organisms must regulate their behavior flexibly in the face of environmental challenges. Failure can lead to a host of maladaptive behavioral traits associated with a range of neuropsychiatric disorders, including attention deficit hyperactivity disorder, autism, and substance use disorders. This maladaptive dysregulation of behavior is influenced by genetic and environmental factors. For example, environmental enrichment produces beneficial neurobehavioral effects in animal models of such disorders. The present study determined the effects of environmental enrichment on a range of measures related to behavioral regulation using a large cohort of male, outbred heterogeneous stock (HS) rats as subjects. Subjects were reared from late adolescence onwards either in pairs in standard housing with minimal enrichment (n = 200) or in groups of 16 in a highly enriched environment consisting of a large multi-level cage filled with toys, running wheels, and shelters (n = 64). Rats were subjected to a battery of tests, including: (i) locomotor response to novelty, (ii) light reinforcement, (iii) social reinforcement, (iv) reaction time, (v) a patch-depletion foraging test, (vi) Pavlovian conditioned approach, (vii) conditioned reinforcement, and (viii) cocaine conditioned cue preference. Results indicated that rats housed in the enriched environment were able to filter out irrelevant stimuli more effectively and thereby regulate their behavior more efficiently than standard-housing rats. The dramatic impact of environmental enrichment suggests that behavioral studies using standard housing conditions may not generalize to more complex environments that may be more ethologically relevant.
(© 2024. The Author(s).)
Databáze: MEDLINE
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