Construction and optimization of multi-platform precision pathways for precision medicine.

Autor: Tran A; School of Mathematics and Statistics, The University of Sydney, Camperdown, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.; Sydney Precision Data Science Centre, The University of Sydney, Camperdown, NSW, Australia., Wang A; Westmead Medical Institute, Westmead, NSW, Australia., Mickaill J; School of Mathematics and Statistics, The University of Sydney, Camperdown, NSW, Australia.; School of Computer Science, The University of Sydney, Camperdown, NSW, Australia., Strbenac D; School of Mathematics and Statistics, The University of Sydney, Camperdown, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.; Sydney Precision Data Science Centre, The University of Sydney, Camperdown, NSW, Australia., Larance M; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia., Vernon ST; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.; Kolling Institute of Medical Research, St Leonards, NSW, Australia., Grieve SM; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.; Department of Radiology, Royal Prince Alfred Hospital, Camperdown, Australia., Figtree GA; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.; Kolling Institute of Medical Research, St Leonards, NSW, Australia., Patrick E; School of Mathematics and Statistics, The University of Sydney, Camperdown, NSW, Australia.; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.; Sydney Precision Data Science Centre, The University of Sydney, Camperdown, NSW, Australia.; Laboratory of Data Discovery for Health Limited (D24H), Science Park, Hong Kong SAR, China., Yang JYH; School of Mathematics and Statistics, The University of Sydney, Camperdown, NSW, Australia. jean.yang@sydney.edu.au.; Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia. jean.yang@sydney.edu.au.; Sydney Precision Data Science Centre, The University of Sydney, Camperdown, NSW, Australia. jean.yang@sydney.edu.au.; Laboratory of Data Discovery for Health Limited (D24H), Science Park, Hong Kong SAR, China. jean.yang@sydney.edu.au.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Feb 21; Vol. 14 (1), pp. 4248. Date of Electronic Publication: 2024 Feb 21.
DOI: 10.1038/s41598-024-54517-8
Abstrakt: In the enduring challenge against disease, advancements in medical technology have empowered clinicians with novel diagnostic platforms. Whilst in some cases, a single test may provide a confident diagnosis, often additional tests are required. However, to strike a balance between diagnostic accuracy and cost-effectiveness, one must rigorously construct the clinical pathways. Here, we developed a framework to build multi-platform precision pathways in an automated, unbiased way, recommending the key steps a clinician would take to reach a diagnosis. We achieve this by developing a confidence score, used to simulate a clinical scenario, where at each stage, either a confident diagnosis is made, or another test is performed. Our framework provides a range of tools to interpret, visualize and compare the pathways, improving communication and enabling their evaluation on accuracy and cost, specific to different contexts. This framework will guide the development of novel diagnostic pathways for different diseases, accelerating the implementation of precision medicine into clinical practice.
(© 2024. The Author(s).)
Databáze: MEDLINE
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