Canalicular-Like Pleomorphic Adenoma of the Parotid Gland: A Recently Classified Tumor Highlighting the Use of Frozen Section Analysis and Surrogate IHC for Gene Rearrangement Defined Subtypes.
| Autor: | Brown AE; Mayo Clinic Alix School of Medicine, Scottsdale, AZ, USA., Eells AC; Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA., Hinni ML; Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA., Schmitt AC; Division of Surgical Pathology, Department of Pathology and Laboratory Medicine, Mayo Clinic Arizona, Phoenix, AZ, USA. |
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| Jazyk: | angličtina |
| Zdroj: | International journal of surgical pathology [Int J Surg Pathol] 2024 Dec; Vol. 32 (8), pp. 1547-1551. Date of Electronic Publication: 2024 Feb 20. |
| DOI: | 10.1177/10668969241231980 |
| Abstrakt: | Canalicular-like pleomorphic adenomas are a relatively recently described entity, that possess features of both canalicular adenomas and pleomorphic adenomas. The presence of unusual HMGA2 -fusion partners (most commonly HMGA2::WIF1 gene fusions) has established canalicular-like pleomorphic adenoma as a distinct entity. The use of intraoperative frozen section analysis and surrogate HMGA2 IHC are 2 tools that can provide the surgical team with valuable insight into intraoperative decision making and final classification of rare tumors of the parotid gland, respectively. We present a case of canalicular-like pleomorphic adenoma and characterize its appearance on frozen section analysis. HMGA2 IHC staining was retroactively performed, assisting in the confirmation of the tumor subtype. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Databáze: | MEDLINE |
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