Changes in wider field swept-source OCT angiography vascular metrics with anti-vascular endothelial growth factor therapy in central retinal vein occlusion.

Autor: Razavi P; Harvard Retinal Imaging Lab, Boston, MA, USA., Baldwin G; Harvard Retinal Imaging Lab, Boston, MA, USA., Garg I; Harvard Retinal Imaging Lab, Boston, MA, USA., Velazquez LM; Harvard Retinal Imaging Lab, Boston, MA, USA.; Retina Service, Massachusetts Eye and Ear, Boston, MA, USA., Garcia M; Harvard Retinal Imaging Lab, Boston, MA, USA., Gan J; Harvard Retinal Imaging Lab, Boston, MA, USA., Choi H; Harvard Retinal Imaging Lab, Boston, MA, USA., Zeng R; Harvard Retinal Imaging Lab, Boston, MA, USA., Vingopoulos F; Harvard Retinal Imaging Lab, Boston, MA, USA., Husain D; Retina Service, Massachusetts Eye and Ear, Boston, MA, USA., Kim LA; Retina Service, Massachusetts Eye and Ear, Boston, MA, USA., Patel NA; Retina Service, Massachusetts Eye and Ear, Boston, MA, USA., Miller JB; Harvard Retinal Imaging Lab, Boston, MA, USA. John_Miller@meei.harvard.edu.; Retina Service, Massachusetts Eye and Ear, Boston, MA, USA. John_Miller@meei.harvard.edu.; Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Retinal Imaging Lab, Harvard Medical School, 243 Charles St., Boston, MA, 02114, USA. John_Miller@meei.harvard.edu.
Jazyk: angličtina
Zdroj: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2024 Jul; Vol. 262 (7), pp. 2111-2120. Date of Electronic Publication: 2024 Feb 20.
DOI: 10.1007/s00417-024-06410-3
Abstrakt: Purpose: To investigate the impact of anti-VEGF therapy on vascular metrics in eyes with macular edema secondary to central retinal vein occlusion (CRVO) using wider field swept-source OCT angiography (WF SS-OCTA).
Methods: We included 23 eyes with macular edema associated with non-ischemic CRVO from 22 patients treated with anti-VEGF therapy (median number of injections: 5 [2-9]). Changes in vessel density (VD), vessel skeletonized density (VSD), and foveal avascular zone (FAZ) parameters were measured using WF SS-OCTA. Visual acuity (VA) and central subfield thickness (CST) were also measured.
Results: Median CST decreased significantly from 369 µm (305-531) to 267 µm (243-300, p < 0.001). VD and VSD parameters in 12 × 12 mm images showed significant reductions. For instance, VSD in the whole retina decreased from a median of 13.37 (11.22-13.74) to 11.29 (9.36-12.97, p = 0.013). Additionally, a significant increase in FAZ circularity was found, suggesting improved microvascular integrity. Significant inverse correlations were found between the number of anti-VEGF injections and all VSD and VD parameters on the 12 × 12 mm images (p < 0.05). Notably, the reductions in VSD and VD on 12 × 12 mm angiograms in the deep capillary plexus (DCP) after each injection significantly correlated with increased logMAR VA (worse VA).
Conclusion: Anti-VEGF therapy in CRVO patients not only mitigates macular edema but also alters the overall microvascular morphology and functionality as revealed by WF SS-OCTA.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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