Serum total testosterone is associated with phosphate and calcium excretion in response to oral phosphate loading in healthy middle-aged males.

Autor: Sharma JK; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada., Turner ME; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada., Paynter AS; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada., Norman PA; Kingston General Health Research Institute, Kingston Health Sciences Centre, Kingston, Ontario, Canada., White CA; Department of Medicine, Queen's University, Kingston, Ontario, Canada., Ward EC; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada., Adams MA; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada., Holden RM; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.; Department of Medicine, Queen's University, Kingston, Ontario, Canada.
Jazyk: angličtina
Zdroj: Andrology [Andrology] 2024 Nov; Vol. 12 (8), pp. 1668-1674. Date of Electronic Publication: 2024 Feb 20.
DOI: 10.1111/andr.13607
Abstrakt: Androgen receptors are expressed in the kidney and serum testosterone is negatively associated with serum phosphate in males, suggesting a role of testosterone in renal phosphate handling. In this cross-sectional study, we examined the association of serum total and free testosterone with acute phosphate and calcium excretion in males in response to an oral phosphate challenge. Thirty-five healthy adult males with normal baseline testosterone levels consumed a 500 mg phosphorus drink and the urinary excretion of minerals, as well as levels of relevant circulating parameters, were assessed at baseline and hourly for 4 h. Serum total testosterone was positively associated with overall phosphate excretion (r = 0.35, p = 0.04) and calcium excretion (r = 0.44, p = 0.00) in response to the challenge. Serum free testosterone was positively associated with post-challenge calcium excretion (r = 0.34, p = 0.048), but significance was not reached for phosphate excretion (r = 0.31, p = 0.07). Serum total and free testosterone were not associated with parathyroid hormone, fibroblast growth factor-23, or vitamin D-key factors implicated in phosphate and calcium regulation. Overall, higher serum total testosterone levels in healthy middle-aged males are associated with a greater capacity to acutely excrete phosphate and calcium after a single oral phosphate challenge, suggesting potential ramifications of testosterone deficiency related to mineral homeostasis.
(© 2024 The Authors. Andrology published by Wiley Periodicals LLC on behalf of American Society of Andrology and European Academy of Andrology.)
Databáze: MEDLINE
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