Oral microbiota and oral squamous cell carcinoma: a review of their relation and carcinogenic mechanisms.

Autor:	Sukmana BI; Oral Biology, Lambung Mangkurat, Banjarmasin, Indonesia., Saleh RO; Department of Medical Laboratory Techniques, Al-Maarif University College, Al-Anbar, Iraq., Najim MA; Department of Biology, College Education for Pure Science, University of Anbar, Al-Anbar, Iraq., Al-Ghamdi HS; Internal Medicine Department, Division of Dermatology, Faculty of Medicine, Albaha University, Albaha, Saudi Arabia., Achmad H; Department of Pediatric Dentistry, Faculty of Dentistry, Hasanuddin University, Indonesia (Lecture of Pediatric Dentistry), Makassar, Indonesia., Al-Hamdani MM; Pharmaceutics Department, College of Pharmacy, Al-Ayen University, Thi-Qar, Iraq., Taher AA; College of Dentistry, The Islamic University, Najaf, Iraq., Alsalamy A; College of Technical Engineering, Imam Ja'afar Al-Sadiq University, Al-Muthanna, Iraq., Khaledi M; Department of Microbiology and Immunology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran., Javadi K; Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	Frontiers in oncology [Front Oncol] 2024 Feb 05; Vol. 14, pp. 1319777. Date of Electronic Publication: 2024 Feb 05 (Print Publication: 2024).
DOI:	10.3389/fonc.2024.1319777
Abstrakt:	Oral Squamous Cell Carcinoma (OSCC) is the most common type of head and neck cancer worldwide. Emerging research suggests a strong association between OSCC and the oral microbiota, a diverse community of bacteria, fungi, viruses, and archaea. Pathogenic bacteria, in particular Porphyromonas gingivalis and Fusobacterium nucleatum , have been closely linked to OSCC. Moreover, certain oral fungi, such as Candida albicans , and viruses, like the human papillomavirus, have also been implicated in OSCC. Despite these findings, the precise mechanisms through which the oral microbiota influences OSCC development remain unclear and necessitate further research. This paper provides a comprehensive overview of the oral microbiota and its relationship with OSCC and discusses potential carcinogenic pathways that the oral microbiota may activate or modulate are also discussed. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Sukmana, Saleh, Najim, AL-Ghamdi, Achmad, Al-Hamdani, Taher, Alsalamy, Khaledi and Javadi.)
Databáze:	MEDLINE
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