Pseudohypoaldosteronism Type II or Gordon Syndrome: A Rare Syndrome of Hyperkalemia and Hypertension With Normal Renal Function.
| Autor: | Manas F; Endocrinology, Henry Ford Health System, Detroit, USA., Singh S; Internal Medicine, Sunrise Hospital and Medical Center, Las Vegas, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Jan 19; Vol. 16 (1), pp. e52594. Date of Electronic Publication: 2024 Jan 19 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.52594 |
| Abstrakt: | Pseudohypoaldosteronism type II (PHA II) or Gordon syndrome is characterized by hyperkalemia, hypertension, hyperchloremic metabolic acidosis, low plasma renin activity, and normal kidney function. We report a rare case of a young adult female patient presenting with abdominal pain, diarrhea, and vomiting. She was hypertensive during the presentation. Blood work showed mild anemia, hyperkalemia, hyperchloremia, and metabolic acidosis, with normal renal function and liver function. Plasma renin activity and aldosterone levels were low-normal. These findings were suggestive of PHA II or Gordon syndrome. It is a rare familial disease, with a non-specific presentation and no specific diagnostic criteria, and physicians should suspect it in patients with hyperkalemia in the setting of normal glomerular filtration, along with hypertension (which can be absent), metabolic acidosis, hyperchloremia, low plasma renin activity, and relatively suppressed aldosterone. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Manas et al.) |
| Databáze: | MEDLINE |
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