Processing speed mediates the relationship between DDR1 and psychosocial functioning in euthymic patients with bipolar disorder presenting psychotic symptoms.

Autor: Aranda S; Institut d'Investigació Sanitària Pere Virgili-CERCA, Reus, Spain.; Hospital Universitari Institut Pere Mata, Reus, Spain.; Universitat Rovira i Virgili, Reus, Spain.; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)-Instituto de Salud Carlos III, Madrid, Spain., Jiménez E; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)-Instituto de Salud Carlos III, Madrid, Spain.; Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, Barcelona, Spain.; Department of Psychiatry, University of the Basque Country (UPV-EHU), Vitoria-Gasteiz, Spain., Canales-Rodríguez EJ; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)-Instituto de Salud Carlos III, Madrid, Spain.; FIDMAG Germanes Hospitalàries Research Foundation, Sant Boi de Llobregat, Barcelona, Spain.; Signal Processing Laboratory (LTS5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Verdolini N; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)-Instituto de Salud Carlos III, Madrid, Spain.; Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, Barcelona, Spain.; FIDMAG Germanes Hospitalàries Research Foundation, Sant Boi de Llobregat, Barcelona, Spain., Alonso S; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)-Instituto de Salud Carlos III, Madrid, Spain.; Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, Barcelona, Spain., Sepúlveda E; Institut d'Investigació Sanitària Pere Virgili-CERCA, Reus, Spain.; Hospital Universitari Institut Pere Mata, Reus, Spain.; Universitat Rovira i Virgili, Reus, Spain.; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)-Instituto de Salud Carlos III, Madrid, Spain., Julià A; Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain., Marsal S; Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain., Bobes J; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)-Instituto de Salud Carlos III, Madrid, Spain.; Department of Psychiatry, Universidad de Oviedo, Oviedo, Spain.; nstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.; Instituto Universitario de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain.; Servicio de Salud del Principado de Asturias (SESPA) Oviedo, Oviedo, Spain., Sáiz PA; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)-Instituto de Salud Carlos III, Madrid, Spain.; Department of Psychiatry, Universidad de Oviedo, Oviedo, Spain.; nstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.; Instituto Universitario de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain.; Servicio de Salud del Principado de Asturias (SESPA) Oviedo, Oviedo, Spain., García-Portilla P; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)-Instituto de Salud Carlos III, Madrid, Spain.; Department of Psychiatry, Universidad de Oviedo, Oviedo, Spain.; nstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.; Instituto Universitario de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain.; Servicio de Salud del Principado de Asturias (SESPA) Oviedo, Oviedo, Spain., Menchón JM; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)-Instituto de Salud Carlos III, Madrid, Spain.; Bellvitge Biomedical Research Institute-IDIBELL, Bellvitge University Hospital, Barcelona, Spain.; Department of Clinical Sciences, University of Barcelona, Barcelona, Spain., Crespo JM; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)-Instituto de Salud Carlos III, Madrid, Spain.; Bellvitge Biomedical Research Institute-IDIBELL, Bellvitge University Hospital, Barcelona, Spain.; Department of Clinical Sciences, University of Barcelona, Barcelona, Spain., González-Pinto A; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)-Instituto de Salud Carlos III, Madrid, Spain.; Department of Psychiatry, University of the Basque Country (UPV-EHU), Vitoria-Gasteiz, Spain.; Araba University Hospital, Bioaraba Research Institute, UPV/EHU, Vitoria-Gasteiz, Spain., Pérez V; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)-Instituto de Salud Carlos III, Madrid, Spain.; Hospital de Mar. Mental Health Institute, Barcelona, Spain.; Neurosciences Research Unit, Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain.; Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona, Spain., Arango C; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)-Instituto de Salud Carlos III, Madrid, Spain.; Institute of Psychiatry and Mental Health, Madrid, Spain.; Hospital General Universitario Gregorio Marañón, Madrid, Spain.; Universidad Complutense, Madrid, Spain., Sierra P; La Fe University and Polytechnic Hospital, Valencia, Spain.; Department of Psychiatry, School of Medicine, University of Valencia, Valencia, Spain., Sanjuán J; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)-Instituto de Salud Carlos III, Madrid, Spain.; Department of Psychiatry, School of Medicine, University of Valencia, Valencia, Spain., Pomarol-Clotet E; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)-Instituto de Salud Carlos III, Madrid, Spain.; FIDMAG Germanes Hospitalàries Research Foundation, Sant Boi de Llobregat, Barcelona, Spain., Vieta E; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)-Instituto de Salud Carlos III, Madrid, Spain.; Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, Barcelona, Spain., Vilella E; Institut d'Investigació Sanitària Pere Virgili-CERCA, Reus, Spain. vilellae@peremata.com.; Hospital Universitari Institut Pere Mata, Reus, Spain. vilellae@peremata.com.; Universitat Rovira i Virgili, Reus, Spain. vilellae@peremata.com.; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM)-Instituto de Salud Carlos III, Madrid, Spain. vilellae@peremata.com.
Jazyk: angličtina
Zdroj: Molecular psychiatry [Mol Psychiatry] 2024 Jul; Vol. 29 (7), pp. 2050-2058. Date of Electronic Publication: 2024 Feb 19.
DOI: 10.1038/s41380-024-02480-1
Abstrakt: The DDR1 locus is associated with the diagnosis of schizophrenia and with processing speed in patients with schizophrenia and first-episode psychosis. Here, we investigated whether DDR1 variants are associated with bipolar disorder (BD) features. First, we performed a case‒control association study comparing DDR1 variants between patients with BD and healthy controls. Second, we performed linear regression analyses to assess the associations of DDR1 variants with neurocognitive domains and psychosocial functioning. Third, we conducted a mediation analysis to explore whether neurocognitive impairment mediated the association between DDR1 variants and psychosocial functioning in patients with BD. Finally, we studied the association between DDR1 variants and white matter microstructure. We did not find any statistically significant associations in the case‒control association study; however, we found that the combined genotypes rs1264323AA-rs2267641AC/CC were associated with worse neurocognitive performance in patients with BD with psychotic symptoms. In addition, the combined genotypes rs1264323AA-rs2267641AC/CC were associated with worse psychosocial functioning through processing speed. We did not find correlations between white matter microstructure abnormalities and the neurocognitive domains associated with the combined genotypes rs1264323AA-rs2267641AC/CC. Overall, the results suggest that DDR1 may be a marker of worse neurocognitive performance and psychosocial functioning in patients with BD, specifically those with psychotic symptoms.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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