The Effects of Sleeve Gastrectomy on the Appetitive Domain of Taste Using the Progressive Ratio Task.

Autor: Althukair NK; Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia., Abdeen GN; Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia. gabdeen@ksu.edu.sa.; Division of Diabetes, Endocrinology and Metabolism, Imperial College London, 5, London, UK. gabdeen@ksu.edu.sa., le Roux CW; Division of Diabetes, Endocrinology and Metabolism, Imperial College London, 5, London, UK.; Diabetes Complications Research Centre, Conway Institute, University College Dublin, 10, Dublin, Ireland.; Gastrosurgical Laboratory, University of Gothenburg, Gothenburg, Sweden., Miras AD; Division of Diabetes, Endocrinology and Metabolism, Imperial College London, 5, London, UK., Alqahtani AR; Department of Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Jazyk: angličtina
Zdroj: Obesity surgery [Obes Surg] 2024 Apr; Vol. 34 (4), pp. 1168-1173. Date of Electronic Publication: 2024 Feb 19.
DOI: 10.1007/s11695-023-07035-x
Abstrakt: Introduction: Sleeve gastrectomy (SG) is an effective treatment for obesity in adolescents. The underlying weight loss mechanism may impact the peripheral and central gustatory system along with reward circuits in the brain. This study aims to assess changes in appetitive behavior in short-, medium-, and long-term follow-up.
Methods: In this prospective observational study, a total of 8 adolescents with obesity who underwent SG and 9 comparator unoperated participants were studied. Appetitive behaviour towards fat and sweet taste stimuli was assessed using the Progressive Ratio Task (PRT) over a 6 year period.
Results: Mean body mass index (BMI) of the surgical patients dropped from 51.5 ± 2.8 kg/m 2 to 31.4 ± 1.9 and 30.9 ± 2.3 kg/m 2 at 1 and 6 years follow-up, respectively. (p < 0.001). The median (interquartile range) total rewards earned during the PRT was 6 (5-7) pre-surgery, 5 (3-6) after one year and 4 (2-4) after six years from surgery (p = 0.007).
Conclusion: SG reduced appetitive behaviour at 1 year with maintained the benefit over 6 years as measured by the progressive ratio task.
(© 2024. The Author(s).)
Databáze: MEDLINE
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