Next-generation direct reprogramming.
| Autor: | Keshri R; Department of Biochemistry, School of Medicine, University of Washington, Seattle, WA, United States.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States., Detraux D; Department of Biochemistry, School of Medicine, University of Washington, Seattle, WA, United States.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States., Phal A; Department of Biochemistry, School of Medicine, University of Washington, Seattle, WA, United States.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States.; Department of Bioengineering, College of Engineering, University of Washington, Seattle, WA, United States., McCurdy C; Department of Biochemistry, School of Medicine, University of Washington, Seattle, WA, United States.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States.; Institute for Protein Design, University of Washington, Seattle, WA, United States., Jhajharia S; Department of Biochemistry, School of Medicine, University of Washington, Seattle, WA, United States.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States., Chan TC; Department of Biochemistry, School of Medicine, University of Washington, Seattle, WA, United States.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States., Mathieu J; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States.; Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA, United States., Ruohola-Baker H; Department of Biochemistry, School of Medicine, University of Washington, Seattle, WA, United States.; Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, WA, United States.; Department of Bioengineering, College of Engineering, University of Washington, Seattle, WA, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in cell and developmental biology [Front Cell Dev Biol] 2024 Feb 02; Vol. 12, pp. 1343106. Date of Electronic Publication: 2024 Feb 02 (Print Publication: 2024). |
| DOI: | 10.3389/fcell.2024.1343106 |
| Abstrakt: | Tissue repair is significantly compromised in the aging human body resulting in critical disease conditions (such as myocardial infarction or Alzheimer's disease) and imposing a tremendous burden on global health. Reprogramming approaches (partial or direct reprogramming) are considered fruitful in addressing this unmet medical need. However, the efficacy, cellular maturity and specific targeting are still major challenges of direct reprogramming. Here we describe novel approaches in direct reprogramming that address these challenges. Extracellular signaling pathways (Receptor tyrosine kinases, RTK and Receptor Serine/Theronine Kinase, RSTK) and epigenetic marks remain central in rewiring the cellular program to determine the cell fate. We propose that modern protein design technologies (AI-designed minibinders regulating RTKs/RSTK, epigenetic enzymes, or pioneer factors) have potential to solve the aforementioned challenges. An efficient transdifferentiation/direct reprogramming may in the future provide molecular strategies to collectively reduce aging, fibrosis, and degenerative diseases. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Keshri, Detraux, Phal, McCurdy, Jhajharia, Chan, Mathieu and Ruohola-Baker.) |
| Databáze: | MEDLINE |
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