An Update on the Pathogenesis of Fascioliasis: What Do We Know?

Autor:	Tanabe MB; Division of Infectious Disease, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA., Caravedo MA; Division of Infectious Disease, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA., Clinton White A Jr; Division of Infectious Disease, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.; Cusco Branch - Alexander von Humboldt Tropical Medicine Institute, Universidad Peruana Cayetano Heredia, Cusco, Peru., Cabada MM; Division of Infectious Disease, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.; Cusco Branch - Alexander von Humboldt Tropical Medicine Institute, Universidad Peruana Cayetano Heredia, Cusco, Peru.
Jazyk:	angličtina
Zdroj:	Research and reports in tropical medicine [Res Rep Trop Med] 2024 Feb 13; Vol. 15, pp. 13-24. Date of Electronic Publication: 2024 Feb 13 (Print Publication: 2024).
DOI:	10.2147/RRTM.S397138
Abstrakt:	Fasciola hepatica is a trematode parasite distributed worldwide. It is known to cause disease in mammals, producing significant economic loses to livestock industry and burden to human health. After ingestion, the parasites migrate through the liver and mature in the bile ducts. A better understanding of the parasite's immunopathogenesis would help to develop efficacious therapeutics and vaccines. Currently, much of our knowledge comes from in vitro and in vivo studies in animal models. Relatively little is known about the host-parasite interactions in humans. Here, we provide a narrative review of what is currently know about the pathogenesis and host immune responses to F. hepatica summarizing the evidence available from the multiple hosts that this parasite infects. Competing Interests: The authors have no financial or conflicts of interest to disclose for this work. (© 2024 Tanabe et al.)
Databáze:	MEDLINE
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