Intra-amniotic Candida albicans Infection Treated With Liposomal Amphotericin B With a Successful Neonatal Outcome.

Autor: Gutiérrez NU; Departamento de Obstetricia, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile., Vergara López MJ; Departamento de Obstetricia, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile., Bustos CÁ; Departamento de Obstetricia, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile., Vidal CC; Departamento de Obstetricia, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile., Carvajal JA; Departamento de Obstetricia, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile., Severino N; Programa de Farmacología y Toxicología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.; Departamento de Medicina Intensiva, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile., Giordano A; Escuela de Química, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Santiago, Chile., Baquedano SU; Departamento de Neonatología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile., Feuerhake T; Departamento de Anatomía Patológica, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile., Rabagliati R; Departamento de Enfermedades Infecciosas del Adulto, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile., Balcells ME; Departamento de Enfermedades Infecciosas del Adulto, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2024 Jan 31; Vol. 11 (2), pp. ofae047. Date of Electronic Publication: 2024 Jan 31 (Print Publication: 2024).
DOI: 10.1093/ofid/ofae047
Abstrakt: Intra-amniotic infection with Candida species is an uncommon but severe condition with high fetal morbimortality and no established clinical guidelines for its management. We report a Candida albicans intra-amniotic infection diagnosed in a 25-week pregnant woman, successfully treated with high-dose liposomal amphotericin B. Pregnancy was prolonged until 30 weeks, and despite persistently positive Candida cultures in amniotic fluid, a healthy newborn was delivered without evidence of systemic infection. Amphotericin concentration was determined at birth, revealing levels over 30 times higher in mother's and cord blood than in the amniotic fluid, probably explaining the clinical protection despite failure in obtaining fungal clearance.
Competing Interests: Potential conflicts of interest. All authors: no reported conflicts.
(© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze: MEDLINE
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