Antibacterial mouthwash alters gut microbiome, reducing nutrient absorption and fat accumulation in Western diet-fed mice.

Autor: Carvalho LRRA; Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, 5B, 17165, Solna, Stockholm, Sweden., Boeder AM; Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, 5B, 17165, Solna, Stockholm, Sweden.; Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Brazil., Shimari M; Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, 5B, 17165, Solna, Stockholm, Sweden., Kleschyov AL; Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, 5B, 17165, Solna, Stockholm, Sweden., Esberg A; Department of Odontology, Umeå University, Umeå, Sweden., Johansson I; Department of Odontology, Umeå University, Umeå, Sweden., Weitzberg E; Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, 5B, 17165, Solna, Stockholm, Sweden.; Department of Perioperative Medicine and Intensive Care, Karolinska Hospital, Stockholm, Sweden., Lundberg JO; Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, 5B, 17165, Solna, Stockholm, Sweden. jon.lundberg@ki.se., Carlstrom M; Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, 5B, 17165, Solna, Stockholm, Sweden. mattias.carlstrom@ki.se.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Feb 18; Vol. 14 (1), pp. 4025. Date of Electronic Publication: 2024 Feb 18.
DOI: 10.1038/s41598-024-54068-y
Abstrakt: Prolonged use of antibacterial mouthwash is linked to an increased risk of systemic disease. We aimed to investigate if disturbing the oral microbiota would impact the lower gut microbiome with functional effects in diet-induced obesity. Mice were exposed to oral chlorhexidine and fed a Western diet (WD). Food intake and weight gain were monitored, and metabolic function, blood pressure, and microbiota were analyzed. Chlorhexidine reduced the number of viable bacteria in the mouth and lowered species richness in the gut but with proportional enrichment of some bacteria linked to metabolic pathways. In mice fed a Western diet, chlorhexidine reduced weight gain, body fat, steatosis, and plasma insulin without changing caloric intake, while increasing colon triglycerides and proteins, suggesting reduced absorption of these nutrients. The mechanisms behind these effects as well as the link between the oral microbiome and small intestinal function need to be pinpointed. While the short-term effects of chlorhexidine in this model appear beneficial, potential long-term disruptions in the oral and gut microbiota and possible malabsorption should be considered.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje