Is the carotenoid production from Phaffia rhodozyma yeast genuinely sustainable? a comprehensive analysis of biocompatibility, environmental assessment, and techno-economic constraints.

Autor: Mussagy CU; Escuela de Agronomía, Facultad de Ciencias Agronómicas y de los Alimentos, Pontificia Universidad Católica de Valparaíso, Quillota 2260000, Chile. Electronic address: cassamo.mussagy@pucv.cl., Dias ACRV; CESAM - Centre for Environmental and Marine Studies, Department of Environment and Planning, University of Aveiro, 3810-193 Aveiro, Portugal., Santos-Ebinuma VC; Department of Engineering of Bioprocesses and Biotechnology, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, Sao Paulo, Brazil., Shaaban Sadek M; Chemical Engineering Department, Faculty of Engineering, Minia University, Egypt., Ahmad M; Biofuel lab, Department of Plant sciences, Quaid-i-Azam University, Islamabad, Pakistan; College of life science, Neijiang Normal University, Neijiang 641000, Sichuan, China., de Andrade CR; Faculty of Dentistry, Department of Physiology and Pathology, Sao Paulo State University 'Júlio de Mesquita Filho', UNESP, Araraquara, SP, Brazil., Haddad FF; School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, Sao Paulo, Brazil., Dos Santos JL; School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, Sao Paulo, Brazil., Scarim CB; School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, Sao Paulo, Brazil., Pereira JFB; University of Coimbra, CIEPQPF, FCTUC, Department of Chemical Engineering, Rua Sílvio Lima, Pólo II - Pinhal de Marrocos, 3030-790 Coimbra, Portugal., Floriano JF; Bioengineering & Biomaterials Group, São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, Brazil., Herculano RD; Terasaki Institute for Biomedical Innovation (TIBI), 11507 W Olympic Blvd, Los Angeles, CA 90064, USA., Mustafa A; Faculty of Engineering, October University for Modern Sciences and Arts (MSA), Giza, Egypt.
Jazyk: angličtina
Zdroj: Bioresource technology [Bioresour Technol] 2024 Apr; Vol. 397, pp. 130456. Date of Electronic Publication: 2024 Feb 16.
DOI: 10.1016/j.biortech.2024.130456
Abstrakt: Microorganisms, such as yeasts, filamentous fungi, bacteria, and microalgae, have gained significant attention due to their potential in producing commercially valuable natural carotenoids. In recent years, Phaffia rhodozyma yeasts have emerged as intriguing non-conventional sources of carotenoids, particularly astaxanthin and β-carotene. However, the shift from academic exploration to effective industrial implementation has been challenging to achieve. This study aims to bridge this gap by assessing various scenarios for carotenoid production and recovery. It explores the use of ionic liquids (ILs) and bio-based solvents (ethanol) to ensure safe extraction. The evaluation includes a comprehensive analysis involving Life Cycle Assessment (LCA), biocompatibility assessment, and Techno-Economic Analysis (TEA) of two integrated technologies that utilize choline-based ILs and ethanol (EtOH) for astaxanthin (+β-carotene) recovery from P. rhodozyma cells. This work evaluates the potential sustainability of integrating these alternative solvents within a yeast-based bioeconomy.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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