Genome analysis of a novel avian atadenovirus reveals a possible horizontal gene transfer.

Autor: Zheng W; School of Life Sciences, Ludong University, Yantai 264000, Shandong, China; Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China; Shandong Breeding Environmental Control Engineering Laboratory, Yantai 264000, Shandong, China., Teng X; Department of Pharmacy, Yantai Yuhuangding Hospital, Yantai 264000, Shandong China., Jiang T; Department of Pulmonary and Critical Care Medicine, Yantai Yuhuangding Hospital, Yantai 264000, Shandong China., Tang W; Shandong Provincial Key Laboratory of Quality Safety Monitoring and Risk Assessment for Animal Products, Jinan 250022, Shandong, China., Jiang L; School of Life Sciences, Ludong University, Yantai 264000, Shandong, China; Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China; Shandong Breeding Environmental Control Engineering Laboratory, Yantai 264000, Shandong, China., Zhu H; School of Life Sciences, Ludong University, Yantai 264000, Shandong, China; Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China; Shandong Breeding Environmental Control Engineering Laboratory, Yantai 264000, Shandong, China., Yu X; School of Life Sciences, Ludong University, Yantai 264000, Shandong, China; Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China; Shandong Breeding Environmental Control Engineering Laboratory, Yantai 264000, Shandong, China., Chen G; School of Life Sciences, Ludong University, Yantai 264000, Shandong, China; Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China; Shandong Breeding Environmental Control Engineering Laboratory, Yantai 264000, Shandong, China., Wang J; School of Life Sciences, Ludong University, Yantai 264000, Shandong, China; Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China; Shandong Breeding Environmental Control Engineering Laboratory, Yantai 264000, Shandong, China., Zhang J; School of Life Sciences, Ludong University, Yantai 264000, Shandong, China; Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China; Shandong Breeding Environmental Control Engineering Laboratory, Yantai 264000, Shandong, China., Qu M; School of Life Sciences, Ludong University, Yantai 264000, Shandong, China; Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China; Shandong Breeding Environmental Control Engineering Laboratory, Yantai 264000, Shandong, China. Electronic address: qumingjuan@ldu.edu.cn., Zhang X; School of Life Sciences, Ludong University, Yantai 264000, Shandong, China; Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China; Shandong Breeding Environmental Control Engineering Laboratory, Yantai 264000, Shandong, China. Electronic address: zhangxingxiao@ldu.edu.cn.
Jazyk: angličtina
Zdroj: Virology [Virology] 2024 May; Vol. 593, pp. 109999. Date of Electronic Publication: 2024 Feb 08.
DOI: 10.1016/j.virol.2024.109999
Abstrakt: We report the discovery and characterization of a novel adenovirus, Zoothera dauma adenovirus (ZdAdV), from a wild bird species, Zoothera dauma (Scaly thrush). This new atadenovirus was discovered by metagenomic sequencing without virus cultivation. Analyses of the full genome sequence revealed that this new virus is a distinct member of the genus Atadenovirus and represents a novel species. ZdAdV has a genome of 34,760 bp with 28 predicted genes and 39% GC content. ZdAdV is the first atadenovirus to contain ORF19, a gene previously found only in aviadenoviruses. Phylogenetic analysis of ORF19 suggests that it was acquired by ZdAdV through horizontal gene transfer from an aviadenovirus. By analyzing all orthologous genes of aviadenovirus, mastadenovirus, atadenovirus, and siadenovirus, we also found potential horizontal gene transfer for the E4 gene in Pigeon aviadenovirus B. Our study widens our knowledge concerning the genetic diversity and evolutionary history of atadenoviruses and their potential for cross-species transmission.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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