Modern insights into the pathophysiology and treatment of pseudoachalasia.
Autor: | Zanini LYK; Department of Surgery, Escola Paulista de Medicina, Federal University of São Paulo, Rua Diogo de Faria 1087 Cj 301, São Paulo, 04037-003, Brazil., Herbella FAM; Department of Surgery, Escola Paulista de Medicina, Federal University of São Paulo, Rua Diogo de Faria 1087 Cj 301, São Paulo, 04037-003, Brazil. herbella.dcir@epm.br., Velanovich V; Department of Surgery, University of South Florida, Tampa, USA., Patti MG; Department of Surgery, University of Virginia, Charlottesville, USA. |
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Jazyk: | angličtina |
Zdroj: | Langenbeck's archives of surgery [Langenbecks Arch Surg] 2024 Feb 17; Vol. 409 (1), pp. 65. Date of Electronic Publication: 2024 Feb 17. |
DOI: | 10.1007/s00423-024-03259-2 |
Abstrakt: | Background: Secondary achalasia or pseudoachalasia is a clinical presentation undistinguishable from achalasia in terms of symptoms, manometric, and radiographic findings, but associated with different and identifiable underlying causes. Methods: A literature review was conducted on the PubMed database restricting results to the English language. Key terms used were "achalasia-like" with 63 results, "secondary achalasia" with 69 results, and "pseudoachalasia" with 141 results. References of the retrieved papers were also manually reviewed. Results: Etiology, diagnosis, and treatment were reviewed. Conclusions: Pseudoachalasia is a rare disease. Most available evidence regarding this condition is based on case reports or small retrospective series. There are different causes but all culminating in outflow obstruction. Clinical presentation and image and functional tests overlap with primary achalasia or are inaccurate, thus the identification of secondary achalasia can be delayed. Inadequate diagnosis leads to futile therapies and could worsen prognosis, especially in neoplastic disease. Routine screening is not justifiable; good clinical judgment still remains the best tool. Therapy should be aimed at etiology. Even though Heller's myotomy brings the best results in non-malignant cases, good clinical judgment still remains the best tool as well. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
Databáze: | MEDLINE |
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