Interactive calculator to estimate insulin sensitivity in type 1 diabetes.

Autor: Januszewski AS; NHMRC Clinical Trials Centre, University of Sydney, Sydney, New South Wales, Australia.; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.; Sydney Pharmacy School, University of Sydney, Sydney, New South Wales, Australia., Niedzwiecki P; Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznan, Poland., Sachithanandan N; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia., Ward GM; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia., O'Neal DN; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia., Zozulinska-Ziolkiewicz DA; Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznan, Poland., Uruska AA; Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznan, Poland., Jenkins AJ; NHMRC Clinical Trials Centre, University of Sydney, Sydney, New South Wales, Australia.; Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Jazyk: angličtina
Zdroj: Journal of diabetes investigation [J Diabetes Investig] 2024 May; Vol. 15 (5), pp. 594-597. Date of Electronic Publication: 2024 Feb 17.
DOI: 10.1111/jdi.14161
Abstrakt: The gold standard for measuring insulin sensitivity (IS) is the hyperinsulinemic-euglycemic clamp, a time, costly, and labor-intensive research tool. A low insulin sensitivity is associated with a complication-risk in type 1 diabetes. Various formulae using clinical data have been developed and correlated with measured IS in type 1 diabetes. We consolidated multiple formulae into an online calculator (bit.ly/estimated-GDR), enabling comparison of IS and its probability of IS <4.45 mg/kg/min (low) or >6.50 mg/kg/min (high), as measured in a validation set of clamps in 104 adults with type 1 diabetes. Insulin sensitivity calculations using different formulae varied significantly, with correlations (R 2 ) ranging 0.005-0.87 with agreement in detecting low and high glucose disposal rates in the range 49-93% and 89-100%, respectively. We demonstrate that although the calculated IS varies between formulae, their interpretation remains consistent. Our free online calculator offers a user-friendly tool for individual IS calculations and also offers efficient batch processing of data for research.
(© 2024 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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